Results 71 to 80 of about 11,496,973 (304)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effect of Different Drying Method on the Nutritional Quality and Antioxidant Activity of Jiangyong Fragrant Ginger Based on Principal Component Analysis

Shipin gongye ke-ji
To comprehensively evaluate the effects of drying methods on the nutritional quality and antioxidant activity of Jiangyong fragrant ginger, seven different drying methods including natural drying (ND), hot air drying (HAD), infrared drying (ID ...
Xinsheng XIAO, Wenjun ZHOU, Meitao FENG, Jialing LI, Liyan JIANG   +4 more
doaj   +1 more source

DRY METHODS OF DEALING WITH URING [PDF]

The American Journal of the Medical Sciences, 1895
n ...
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of Drying Method on Sulfur Dioxide Content in Edible Mushrooms and Endogenous Transformation Factors

Shipin gongye ke-ji
In this study, dietary risk assessment of sulfur dioxide content in both fresh and dried commercially available edible mushrooms (Tremella fuciformis, Lentinus edodes, and Agaricus blazei) was conducted through risk quotient and point assessment methods.
Yiming TIAN, Chun XU, Qiao YANG, Xinfang ZHANG, Songlin CHANG, Jiali REN   +5 more
doaj   +1 more source

Functional properties of dried tarragon affected by drying method [PDF]

, 2018
[EN] arragon is a small shrubby perennial herb in the Asteraceae family. It is cultivated for the use of its aromatic leaves in seasoning, salads, sauces, vinegars, mustard and spices.
Atar, Gamze, Banu Koç, Gamze Atar, Nazan Çağlar, Koç, Banu, Çağlar, Nazan   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Drying of Heat Sensitive Materials of High Moisture Content in Mechanically Spouted Bed of Inert Particles [PDF]

, 2008
In drying operation the material characteristics such as heat sensitivity, moisture content and particle size are of great importance, which should be taken into account in selection of proper design and conditions for the process.
Gyenis, János, Pallai-Varsányi, E., Tóth, J.   +2 more
core   +1 more source

New Methods for Assessing External Sulfate Attack on Cement-Based Specimens

Applied Sciences
This paper presents two original methods for monitoring and evaluating concrete specimens/structures affected by external sulfate attack (ESA). The first is a drying method developed to assess the penetration depth of sulfate ions in a concrete structure,
Othman Omikrine Metalssi, Marc Quiertant, Mike Jabbour, Véronique Baroghel-Bouny   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source