Results 71 to 80 of about 684,516 (276)

Identifying and evaluating parallel design activities using the design structure matrix [PDF]

open access: yes, 2005
This paper describes an approach based upon the Design Structure Matrix (DSM) for identifying, evaluating and optimising one aspect of CE: activity parallelism.
Duffy, A.H.B.   +2 more
core  

Direct sampling method for anomaly imaging from S-parameter

open access: yes, 2018
In this paper, we develop a fast imaging technique for small anomalies located in homogeneous media from S-parameter data measured at dipole antennas. Based on the representation of S-parameters when an anomaly exists, we design a direct sampling method (
Park, Won-Kwang
core   +1 more source

Ionic Liquid‐Enhanced 3D Printed Flexible Resin for Pressure‐Sensing Applications

open access: yesAdvanced Materials Technologies, EarlyView.
A 3D‐printed resin–ionic liquid (IL) composite forms gyroid ionotronic architectures showing dynamic ionic migration under compression. Impedance analysis reveals distinct frequency responses across three topologies at high IL concentrations.
Nelson Pereira   +4 more
wiley   +1 more source

Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects

open access: yesAdvanced Science, EarlyView.
The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su   +14 more
wiley   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

Intelligent design guidance [PDF]

open access: yes, 2003
This paper presents results from an investigation regarding the use of the Design Structure Matrix (DSM) as a means to guide a designer through the calculation of numerical relationships within the early design system Designer.
Duffy, Alex H. B.   +3 more
core  

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

open access: yesAdvanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang   +12 more
wiley   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

open access: yesAdvanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai   +12 more
wiley   +1 more source

Gate-tuned quantum Hall states in Dirac semimetal (Cd1-xZnx)3As2

open access: yes, 2018
The recent discovery of topological Dirac semimetals (DSM) has provoked intense curiosity not only on Weyl physics in solids, but also on topological phase transitions originating from DSM.
Kawasaki, Masashi   +6 more
core   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

open access: yesAdvanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding   +5 more
wiley   +1 more source

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