Results 121 to 130 of about 181,458 (295)

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

Improved Ultra-Dense Connection Provision Capability of Concurrent Upstream and Direct Inter-ONU Communication IMDD PONs by P2MP Flexible Optical Transceivers

Photonics
To cost-effectively meet 6G latency requirements, concurrent upstream and direct inter-optical network unit (ONU) communication passive optical networks (PONs) based on flexible point-to-multipoint (P2MP) optical transceivers and intensity modulation and
Lin Chen, Han Yang, Shenming Jiang, Wei Jin, Jiaxiang He, Roger Philip Giddings, Yi Huang, Md. Saifuddin Faruk, Xingwen Yi, Jianming Tang   +9 more
doaj   +1 more source

Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium‐glucose cotransporter 2 inhibitor users

British Journal of Clinical Pharmacology, EarlyView.
Abstract Introduction Active surveillance of adverse events using healthcare data is emerging as complementary to the monitoring of spontaneous reports and stand‐alone pharmacoepidemiologic studies. The risk of urinary tract infections (UTIs) was listed as a special warning for sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) when marketed in Europe
Haoxin Le, Dilsad Simay Peker, Lukas Frederic Westphal, Nikolai Brun, Christine Erikstrup Hallgreen, Morten Andersen   +5 more
wiley   +1 more source

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Design of experiments‐guided membrane capture facilitates integration of continuous virus inactivation using Phi6 as a surrogate virus in an intensified downstream process

Biotechnology Progress, EarlyView.
Abstract The growing demand for cost‐efficient and flexible biomanufacturing has increased interest in process‐intensified downstream platforms. This study evaluates an intensified monoclonal antibody (mAb) purification sequence, where two unit operations traditionally performed in batch mode—Protein A capture and low pH virus inactivation (VI)—are ...
Mario Grünberg, Lisa Lipski, Gabriel Fisicaro, Thomas Duvignau, Karolina Meyer‐Heinrichs, Diana Carmen Mocsy, Thomas‐Josef Filz, Bastian Quaas, Alexandra Stützer   +8 more
wiley   +1 more source

Random forest regression for catalyst performance prediction and validation of tri‐reforming of methane (TRM)

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Carbon dioxide‐reduced hydrogen can be synthesized through various methods such as dry‐reforming (DRM), steam reforming (SMR), and partial oxidation (POX). Tri‐reforming of methane (TRM) is a promising technology which combines all the above‐mentioned processes for the simultaneous production of hydrogen and syngas with high energy efficiency.
Paulo A. L. de Souza, Raja Muhammad Afzal, Felipe Gomes Camacho, Nader Mahinpey   +3 more
wiley   +1 more source

A New Strategy to Design Reconfigurable Rivest–Shamir–Adleman (RSA) Accelerators

International Journal of Circuit Theory and Applications, EarlyView.
A reconfigurable FPGA‐based RSA accelerator is proposed using compression‐based modular multipliers combined with pseudomoduli arithmetic. The approach maps modular exponentiation to low‐cost arithmetic domains and applies a correction stage, achieving significant improvements in delay, operating frequency, and delay–area efficiency compared with ...
Augusto C. B. Vassoler, Gabriel B. M. Fernandes, Lucas R. Kieslich, Eduardo A. Bezerra, Hector Pettenghi   +4 more
wiley   +1 more source

Scalable Reverse Converters for the Moduli Set {2n+1−1,2n−1,2n−1−1}$$ \left\{{2}^{n+1}-1,{2}^n-1,{2}^{n-1}-1\right\} $$ (n$$ n $$ Even)

International Journal of Circuit Theory and Applications, EarlyView.
This work explores the conversion from residues to binary representation in RNS using the Chinese remainder theorem (CRT) or mixed radix conversion (MRC) algorithms. The proposed approach relocates CRT multiplicative inverses to the arithmetic stage without extra cost, improving scalability while achieving speedups over state‐of‐the‐art MRC ...
Gabriel B. M. Fernandes, Hector Pettenghi, Lucas R. Kieslich   +2 more
wiley   +1 more source

Critical expansion points: Mechanical signs of surrounding rock instability

Deep Underground Science and Engineering, EarlyView.
This study proposes the Rock Bearing‐Expansion Model (RockBEM) with critical expansion points (CEPs) to quantify post‐peak damage stages in deep‐buried rock masses via plane strain compression test (PSCT). CEP hysteresis&interval ratios reveal bearing performance dynamics and failure severity, advancing mechanistic insights into deep underground rock ...
Jiaqi Wen, Chang Deng, Haijun Wang, Lei Tang, Jihong Yu   +4 more
wiley   +1 more source

Harnessing the power of machine and deep learning for transferring joint species distribution models considering the structure of biotic interactions

Ecography, EarlyView.
The transferability of single or joint species distribution models ((j)SDMs) depends on their ability to predict beyond the observed environmental range and to remain consistent despite shifts in biotic interactions. Transfer accuracy may be improved by recent advances in the application of deep learning that provide greater flexibility and potentially
Marco Basile, Maximilian Pichler, Francesco Valerio, Lorenzo Balducci, Francesco Chianucci, Sérgio Godinho, Francesco Rota, Frédéric Archaux, Christophe Bouget, Gediminas Brazaitis, Thomas Campagnaro, Ettore D'Andrea, Luc De Keersmaeker, Wouter Dekoninck, Pallieter De Smedt, Zoltán Elek, Itziar García‐ Mijangos, Frédéric Gosselin, Marion Gosselin, Andrin Gross, Elena Haeler, Sebastian Kepfer‐ Rojas, Nathalie Korboulewsky, Daniel Kozák, Thibault Lachat, Carlos Miguel Landivar Albis, Anja Leyman, Xiang Liu, Anders Mårell, Radim Matula, Martin Mikoláš, Péter Ódor, Yoan Paillet, Kastytis Šimkevičius, Tommaso Sitzia, Silvia Stofer, Nicolas Strebel, Miroslav Svoboda, Flóra Tinya, Mariana Ujházyová, Kris Vandekerkhove, Kris Verheyen, Michael Wohlwend, Fotios Xystrakis, Sabina Burrascano   +44 more
wiley   +1 more source