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Biological comparison of DTPA and SCN-benzyl-EDTA as chelating agents for indium-labeling of antibodies

Biological comparison of DTPA and SCN-benzyl-EDTA as chelating agents for indium-labeling of antibodies
openaire   +1 more source

Effects of the chelating agent DTPA on naturally accumulating metals in the body

Toxicology Letters, 2021
Diethylenetriaminepentaacetate (DTPA) is the most widely used chelating agent for Pu and Am. Volunteers were assigned to receive intravenous injections or aerosol inhalations of 1 g of DTPA on days 1-4; volunteers received once daily injections of CaDTPA or ZnDTPA, CaDTPA inhalation as an aerosol, or CaDTPA injection on day 1 and ZnDTPA on days 2-4 ...
Makoto Akashi, Takashi Ikeda, Horibuchi-Matsuzaki Shiori   +2 more
exaly   +5 more sources

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Straightforward Synthesis of a Novel Maleimide‐DTPA Bifunctional Chelating Agent

Synthetic Communications, 2005
Abstract An extremely easy and multigram scale synthesis of a new maleimide‐DTPA derivative is described. This bifunctional chelating agent finds application in bioconjugate chemistry because the maleimido group allows easy labeling of thiol‐containing molecules (e.g., proteins, peptides) and the DTPA moiety ensures a strong and stable coordination of ...
Luciano Lattuada
exaly   +2 more sources

On the reaction of iron(III) with chromium(III)–DTPA chelating agent

Polyhedron, 2000
The reaction of iron(III) with chromium(III)–DTPA ‘chelating agent’ has been investigated, in aqueous solution, by measuring both hydrogen ion concentration and emf of the iron(III)/iron(II) couple.
R Bucci, A Napoli
exaly   +3 more sources

Evaluating the corrosion index of DTPA at different conditions - key of improving the performance of chelating agents in field treatments

Geoenergy Science and Engineering, 2023
Jaber Al Jaberi, Abdullah S Sultân, Shirish Patil   +2 more
exaly   +2 more sources

EDTA and DTPA analogues of dipalmitoylphosphatidylethanolamine as lipopphilic chelating agents for metal labeling of LDL

Tetrahedron Letters, 1996
Abstract Two lipophilic chelating agents (L) prepared by reaction of dipalmitoylphosphatidylethanolamine with the bis(anhydride) form of ethylenediaminetetraacetic acid (EDTA) or diethylenetriaminepentaacetic acid (DTPA) were characterized. L, indium-L or gadolinium-L complexes are soluble in buffered solutions and may be used for metal labeling of ...
Françoise Nepveu
exaly   +2 more sources

De Novo Synthesis of a New Diethylenetriaminepentaacetic Acid (DTPA) Bifunctional Chelating Agent

Bioconjugate Chemistry, 2002
Diethylene triamine pentaacetic acid (DTPA) has been in extensive use as a metal chelator in the development of radiopharmaceuticals and contrast agents. The former application uses DTPA mostly as a bifunctional chelating agent (BCA) conjugated to tumor-targeting vehicles (TTVs) such as monoclonal antibodies (MAbs) and receptor-directed peptides. A new
Ahmad, Safavy, Dale C, Smith, Alireza, Bazooband, Donald J, Buchsbaum   +3 more
openaire   +2 more sources

Should DTPA, an Aminocarboxylic acid (ethylenediamine-based) chelating agent, be considered a developmental toxicant?

Regulatory Toxicology and Pharmacology, 2018
Aminocarboxylic acid (ethylenediamine-based) chelating agents, such as DTPA and EDTA, are widely used in a variety of products and processes. Recently the European RAC proposed to classify DTPA as a developmental toxicant Category 1B according to CLP.
Josje, Arts, Steffen, Bade, Marta, Badrinas, Nicholas, Ball, Stuart, Hindle   +4 more
exaly   +3 more sources

EFFECT OF ORALLY ADMINISTERED CHELATING AGENTS EDTA, DTPA AND FRUCTOSE ON RADIOIRON ABSORPTION IN MAN

Australasian Annals of Medicine, 1967
SummaryIn order to assess the effect of orally administered chelating agents on iron absorption in man, experiments were carried out with ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA) and fructose. Sixty‐eight radio‐iron absorption tests were carried out on 17 hæmatologically normal adult volunteers. The dose in each
P S, Davis, D J, Deller
openaire   +2 more sources