Results 231 to 240 of about 440,036 (332)

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Dynamic Organellar Mapping in yeast reveals extensive protein localization changes during ER stress. [PDF]

Nat Commun
Platzek A, Odehnalová K, Schessner JP, Borner GHH, Schuck S.   +4 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Hospital-family collaborative DTT intervention to reduce the parenting stress through improving core symptoms and family functioning in children with autism spectrum disorder: a randomized controlled trial. [PDF]

Front Pediatr
Dai M, Li J, Chen X, Chen L, Tang X, Yu H, Qiu Y, Yang Y.   +7 more
europepmc   +1 more source

DTT-BSR: GAN-based DTTNet with RoPE Transformer Enhancement for Music Source Restoration [PDF]

Shihong Tan, Haoyu Wang, Youran Ni, Yingzhao Hou, Jiayue Luo, Zipei Hu, Han Dou, Zerui Han, Ningning Pan, Yuzhu Wang, Gongping Huang   +10 more
openalex  

Results on the 1 MW CW 170 GHz gyrotron TH1509UA for ITER and DTT at the FALCON test stand [PDF]

F. Braunmueller, T. Goodman, J. Genoud, F. Albajar, S. Alberti, Konstantinos A. Avramidis, Ruggero Bertazzoni, W. Bin, Daniele Bonetti, A. Bruschi, Antonio Cammi, M. Cavinato, Ioannis Chelis, Davide Dall’Acqua, Rosa Difonzo, Lukas Feuerstein, Eleonora Gajetti, G. Gantenbein, S. Garavaglia, Jérémy Gontard, G. Granucci, J.-P. Hogge, S. Illy, Carolina Introini, Zisis C. Ioannidis, John Jelonnek, J. Jin, Alberto Leggieri, François Legrand, Christophe Liévin, Rodolphe Marchesin, Ijaze M. Oumar, Oriol Picas, A. Romano, T. Rzesnicki, F. H. Sánchez, Laura Savoldi, Sebastian Stanculovic, Ioannis G. Tigelis, Etienne Vallée, M. Thumm   +40 more
openalex   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Bioactive and Injectable Granular Hydrogels Incorporating Decellularized Extracellular Matrix. [PDF]

ACS Biomater Sci Eng
Trindade D, Di Caprio N, Maurício AC, Alves N, Moura C, Burdick JA.   +5 more
europepmc   +1 more source

Fluid loads on LOFT DTT shrouds located in reactor vessel downcomer and DTT thermal loads during nuclear LOCE

, 1978
G. Kyllingstad
openalex   +2 more sources

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

Advanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel   +9 more
wiley   +1 more source