Results 261 to 270 of about 440,036 (332)

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Bacterial infection elicits the <i>Aedes aegypti</i> unfolded protein response. [PDF]

Open Biol
Magistrado D, Short SM.
europepmc   +1 more source

Variable-Depth Complementary Spiral Cooling Channel Design for the Steerable Ecrh Mirrors of Dtt

A. Pagliaro, Francesco Braghin, A. Bruschi, Daniele Busi, Eliana De Marchi, F. Fanale, G. Granucci, A. Romano, Fabio Zanon   +8 more
openalex   +1 more source

Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, EarlyView.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source

Unlocking tropical adaptation: novel flowering time genes implicate JA and ROS signaling in maize. [PDF]

BMC Plant Biol
Zhu J, Jiang F, Bi Y, Sun J, Hong X, Ijaz B, Fan X.   +6 more
europepmc   +1 more source

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, EarlyView.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

In the trail of the crime scene dog: Processing of human DNA from outdoor samples. [PDF]

Forensic Sci Int Synerg
Forsberg C, Hedell R, Ansell R, Hedman J.   +3 more
europepmc   +1 more source

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science, EarlyView.
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
wiley   +1 more source

Application of differential scanning fluorimetry to X-ray protein crystallography. [PDF]

IUCrJ
Sato Y, Senda T.
europepmc   +1 more source

Rapid prototyping of control modules for the DTT Plasma Control System

Sara Dubbioso, Daniele Ottaviano, Federico Fiorenza, G. De Tommasi, N. Ferron, G. Manduchi, E. Acampora, R. Ambrosino   +7 more
openalex   +1 more source