Results 51 to 60 of about 440,036 (332)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Sickle cell disease status among school adolescents and their tribal community in South Gujarat [PDF]
, 2009 Objectives: to create awareness, to screen samples of school adolescents and then to reach their community through them by doing surveillance for sickle cell disease. Design: Field based cross-sectional study. Settings: St Xavier`s high school and Vanraj
Chudasama, Rajesh K +3 more
core +1 more source
Simultaneous detection of the nonlinear restoring and excitation of a forced nonlinear oscillation: an integral approach [PDF]
, 2015 We address in this article, how to calculate the restoring characteristic and the excitation of a nonlinear forced oscillating system. Under the assumption that the forced nonlinear oscillator has a periodic solution with period, we constructed a system ...
Ahmad, Fayyaz +3 more
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Archeomatica, 2014 Nel XXI secolo l’informatica e le telecomunicazioni svolgono un ruolo fondamentale riguardo all’accesso e alla valorizzazione dei contenuti informativi. Le risorse in formato elettronico, corredate da elementi multimediali ed inserite in sistemi dedicati,
Franco Liberati
doaj
, 2016 We propose a new bi-intuitionistic type theory called Dualized Type Theory (DTT). It is a simple type theory with perfect intuitionistic duality, and corresponds to a single-sided polarized sequent calculus.
Eades III, Harley +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 2015 We present a model of dependent type theory (DTT) with Pi-, 1-, Sigma- and intensional Id-types, which is based on a slight variation of the category of AJM-games and history-free winning strategies.
Abramsky, Samson +2 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Morphological development and cytochrome c oxidase activity in Streptomyces lividans are dependent on the action of a copper bound Sco protein [PDF]
, 2013 Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics.
Calabrese L +5 more
core +2 more sources