Results 51 to 60 of about 84,127 (307)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A Left/Right-Handed Dual Circularly-Polarized Antenna With Duplexing and Filtering Performance

IEEE Access, 2019
A shared-radiator dual-band dual-sense circularly-polarized (CP) microstrip antenna with duplexing and filtering functions is presented. For each band, there is a coupling network, which consists of a hairpin resonator, a straight slot, and a U-slot, and
Jian-Feng Li, Duo-Long Wu, Gary Zhang, Yan-Jie Wu, Chun-Xu Mao   +4 more
doaj   +1 more source

Dual-Band Circularly Polarized Omni-Directional Biconical Antenna With Double-Circular Parallelepiped Elements for WLAN Applications

IEEE Access, 2022
This research proposes a novel dual-band (2.45/5.80 GHz) omnidirectional circularly polarized (CP) biconical antenna with double-circular parasitic parallelepiped elements for wireless local area network (WLAN) applications.
Pisit Janpangngern, Danai Torrungrueng, Monai Krairiksh, Chuwong Phongcharoenpanich   +3 more
doaj   +1 more source

Novel dual-band single circular polarization antenna feeding network for satellite communications [PDF]

, 2014
In this paper a novel dual-band single circular polarization antenna feeding network for satellite communications is presented. The novel antenna feed chain1 is composed of two elements or subsystems, namely a diplexer and a bi-phase polarizer.
Leal Sevillano, Carlos Alberto, Montejo Garai, José R., Rebollar Machain, Jesús María, Ruiz Cruz, Jorge A.   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Pattern Synthesis of Dual-band Shared Aperture Interleaved Linear Antenna Arrays [PDF]

, 2014
This paper presents an approach to improve the efficiency of an array aperture by interleaving two different arrays in the same aperture area. Two sub-arrays working at different frequencies are interleaved in the same linear aperture area. The available
Ding, J., Guo, C. J., Guo, H.
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Four-Port CSRR-Loaded Dual-Band MIMO Antenna With Suppressed Higher Order Modes

IEEE Access, 2022
In this paper, we propose a compact four-port dual-band MIMO antenna with suppressed higher order modes (HOMs). First, complementary split ring resonator (CSRR) loading is used on a square microstrip antenna to achieve simultaneous miniaturization and ...
Jogesh Chandra Dash, Debdeep Sarkar
doaj   +1 more source