Results 131 to 140 of about 310,283 (288)

Design of a Compact Dual-Band and Dual-Mode Wearable Antenna for WBAN Applications

Sensors
This paper presents a novel design of a compact dual-band dual-mode wearable antenna. The antenna is fed through a single coaxial feed probe, which excites TM01 and TM11 modes at 2.45 GHz and 5.8 GHz, respectively.
Wei Zhang, Wenran Li, Xiaoyu Feng, Chen Zhao, Yan Li, Xiaoyi Liao   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Design and simulation of dual-mode structure of two-dimensional-mode resonators based on AlN film

Nantong Daxue xuebao. Ziran kexue ban
Two-dimensional-mode resonators (2DMR) based on aluminum nitride (AlN) piezoelectric thin films have attracted extensive attention in the industry due to their high effective electromechanical coupling coefficient (k2eff) and compatibility with ...
ZHAO Jicong; WANG Xingyu; SUN Haiyan
doaj   +1 more source

An engineering treatise on the CARE II dual mode and coverage models [PDF]

A mathematical model used to calculate the reliability of any dual-mode, spare-switching computer system was described, and some illustrative examples were presented.

core   +1 more source

Dual-mode floating-point adder architectures

Journal of Systems Architecture, 2008
Most modern microprocessors provide multiple identical functional units to increase performance. This paper presents dual-mode floating-point adder architectures that support one higher precision addition and two parallel lower precision additions. A double precision floating-point adder implemented with the improved single-path algorithm is modified ...
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Dual-Mode Plasmonic Colorimetric/Photothermal Aptasensor for OTA: Based on a Mn²⁺-Powered DNA Walker for Mediating AuNB Growth

Foods
The sensitive and efficient detection of ochratoxin A (OTA) is critical for protecting agricultural ecosystems and public health. A dual-mode plasmonic colorimetric/photothermal aptasensor, based on a Mn2+-powered DNA walker for mediating gold ...
Zhi Li, Quan Liu, Hongwei Zhang, Yu Xiao, Ming Li, Xiaojie Chai, Jianlong Ji, Jindong Li, Shu Qin   +8 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source