Results 121 to 130 of about 8,494,890 (345)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
International Journal of Nanomedicine, 2019 Xiaoyu Li,* Shujun Xia,* Wei Zhou, Ri Ji, Weiwei Zhan Ultrasound Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China *These authors contributed equally to this work Background: Multimodal contrast agents with
Li X, Xia S, Zhou W, Ji R, Zhan W
doaj
A High-Harmonic-Rejection W-Band Mixer-Based Frequency Tripler With a Dual-Mode Notch Filter
IEEE Journal of MicrowavesThis paper presents a W-band mixer-based frequency tripler featuring a dual-mode notch filter (DMNF) that simultaneously suppresses fundamental ($f{_{0}}$) and second harmonic (2$f{_{0}}$) while boosting the desired third harmonic (3$f{_{0}}$), enabling ...
Dongho Yoo, Byung-Wook Min
doaj +1 more source
Dual-Mode FRET and BRET Sensors for Detecting cAMP Dynamics
, 2019 Genetically encoded fluorescent and luminescent indicators have revolutionized our ability to monitor physiology in real time, but the separate development of new sensors for each of these imaging modalities involves substantial effort and resources ...
Alexander L. Tesmer (7375850) +2 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Paired electromagnetically induced transparency with dual mode laser: A step towards EIT-Comb
, 2008 Coupled electromagnetically induced transparency (EIT) has been observed with a dual mode control laser.
Iftiquar, SM
core
Dual-Mode Resonator for Simultaneous Permittivity and Thickness Measurement of Dielectrics
, 2020 This paper presents a microwave sensor for simultaneous measurement of permittivity and thickness in dielectric materials. The sensor is made of a dual-mode magnetic- LC resonator coupled to a microstrip transmission line. Due to a dual-mode resonance of
Amir Ebrahimi (18027895) +2 more
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source