Results 121 to 130 of about 3,408,611 (301)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Dual-Mode FRET and BRET Sensors for Detecting cAMP Dynamics

open access: yes, 2019
Genetically encoded fluorescent and luminescent indicators have revolutionized our ability to monitor physiology in real time, but the separate development of new sensors for each of these imaging modalities involves substantial effort and resources ...
Alexander L. Tesmer (7375850)   +2 more
core   +1 more source

Design of a Compact Dual-Band and Dual-Mode Wearable Antenna for WBAN Applications

open access: yesSensors
This paper presents a novel design of a compact dual-band dual-mode wearable antenna. The antenna is fed through a single coaxial feed probe, which excites TM01 and TM11 modes at 2.45 GHz and 5.8 GHz, respectively.
Wei Zhang   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Dual-Mode Reconfigurable Frequency-Selective Surface for Switching Between Narrowband and Wideband Applications

open access: yesMicromachines
This study presents a reconfigurable frequency-selective surface (R-FSS) designed to dynamically switch between WLAN, WiMAX, and sub-6 GHz band frequencies.
Batuhan Uslu   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Dual-Mode Dual-Band Microstrip Filters

open access: yes, 2009
A compact dual-band microstrip bandpass filter is proposed using dual-mode resonators. Two microstrip loop resonators, one within the other, are employed to obtain dual-mode dual-band filter responses.
Gorur, Adnan, Karpuz, Ceyhun
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Dual-Mode Resonator for Simultaneous Permittivity and Thickness Measurement of Dielectrics

open access: yes, 2020
This paper presents a microwave sensor for simultaneous measurement of permittivity and thickness in dielectric materials. The sensor is made of a dual-mode magnetic- LC resonator coupled to a microstrip transmission line. Due to a dual-mode resonance of
Amir Ebrahimi (18027895)   +2 more
core  

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