Results 121 to 130 of about 347,909 (355)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Compact and High-Selectivity SIW Multi-Channel Diplexers and Dual-Band Filters Based on the Lowest-Order Dual-Mode Box-Like Topology

IEEE Access
This paper proposes a class of compact, sharp roll-off, and substrate-integrated-waveguide (SIW) multi-channel diplexers and dual-band filters based on the lowest-order dual-mode (DM) box-like topology.
Pei-Ling Chi, Ta-Chih Yeh, Tao Yang
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Chung-Li, Taiwan dual mode (Doppler and spaced antenna) VHF radar: Preliminary specifications [PDF]

, 1983
A major unresolved question in the field of atmospheric research using VHF radar techniques is the relative merit of the two most widely used systems. These systems are the Doppler method and the spaced antenna method.
Brosnahan, J. W., Chao, J., Rottger, J.
core   +1 more source

Review for "Sliding mode and current observer‐based direct power control of dual active bridge converter with constant power load"

, 2020

openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dual-Mode Microfluidic Workstation for Rapid Detection of Multiple Mycotoxins on Chip

Foods
The assurance of food safety requires sensitive monitoring of multiple mycotoxins due to their severe impacts on the food industry and high health risks posed to consumers.
Binfeng Yin, Shiyu Zeng, Jun Liu, Rashid Muhammad, Zhuoao Jiang, Gang Tan, Qi Yang   +6 more
doaj   +1 more source

The convertible engine: A dual-mode propulsion system [PDF]

A variable inlet guide vane (VIGV) convertible engine that could be used to power future high-speed rotorcraft was tested on an outdoor stand. The engine ran stably and smoothly in the turbofan, turboshaft, and dual (combined fan and shaft) power modes ...
Mcardle, Jack G.
core   +1 more source

Optimizing the G/T ratio of the DSS-13 34-meter beam-waveguide antenna [PDF]

, 1992
Calculations using Physical Optics computer software were done to optimize the gain-to-noise-temperature (G/T) ratio of Deep Space Station (DSS)-13, the Deep Space Network's (DSN's) 34-m beam-waveguide antenna, at X-band for operation with the ultra-low ...
Esquivel, M. S.
core   +1 more source