Results 161 to 170 of about 347,909 (355)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Maneuvering the Dual Mode Manned/Automated Lunar Roving Vehicle, June 1969 - March 1970 [PDF]

Digital maps of hazards to movement for dual mode Lunar Roving ...
Lewandowski, G. M., Wood, W. F.
core   +1 more source

A DUAL-MODE RESONATOR-FED GAP COUPLED FILTERING ANTENNA WITH IMPROVED SELECTIVITY AND BANDWIDTH

, 2019
Yun Wang, Ya-Liang Chen, Jian-Feng Qian, Yan Cao   +3 more
openalex   +1 more source

Dual-parameter femtosecond mode-locking pulse generation in partially shared all-polarization-maintaining fiber Y-shaped oscillator with a single saturable absorber

, 2023
Chen Bai, Feng Ye, Weiguang Zhang, Junying Zhang, Tong Zhang, Chao Mei, Pandi Liu, Zhaojin Fan, Jiangxiao Qian, Jia Yu   +9 more
openalex   +2 more sources

Analysis on the Training Model of “Integration of Industry and Education with Dual Education Mode” for Composite Talents in Mechanical and Electrical Engineering in Higher Vocational Education [PDF]

, 2023
Wenhua Gong
openalex   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Magnetic Graphene Oxide Nanocomposite as Dual-Mode Genosensor for Ultrasensitive Detection of Oncogenic MicroRNA

, 2023
Chi‐Hsien Liu, Pinpinut Kabinsing, Pravanjan Malla, Wei-Chi Wu, Paiboon Sreearunothai   +4 more
openalex   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Technology requirements for advanced earth-orbital transportation systems, dual-mode propulsion [PDF]

The application of dual-mode propulsion concepts to fully reusable single-stage-to-orbit (SSTO) vehicles is discussed. Dual-mode propulsion uses main rocket engines that consume hydrocarbon fuels as well as liquid hydrogen fuel.
Haefeli, R. C., Hurley, J. B., Littler, E. G., Winter, M. G.   +3 more
core   +1 more source