Results 191 to 200 of about 310,283 (288)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

A multi-functional MEMS resonator for simultaneously dual-mode physical sensing and ppb-level timing. [PDF]

Microsyst Nanoeng
Xu J, Xi J, Wang C, Kraft M, Liu H, Martins RP, Mak PI, Wang Y.   +7 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Polarization-Multiplexed Metalens Enables Switchable and Compact Chromatic Confocal Sensing with Dual-Mode Precision Control. [PDF]

Adv Sci (Weinh)
Zhao Z, Jiang Y, Lai T, Peng W, Hu Y, Chen S.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

FGAN@PB NP Nanozyme-Based Colorimetric-Photothermal Dual-Mode Immunosensor for Malachite Green Detection. [PDF]

Biosensors (Basel)
Wu MF, Li JM, Li S, Wu MH, Chen RS, Liu YC, Liu JN, Xu ZL, Yang YC, Li JD, Lei QY, Zhan SM, Luo L.   +12 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Dual-Mode Sensor with Saturated Mechanochromic Structural Color Enhanced by Black Conductive Hydrogel for Interactive Rehabilitation Monitoring. [PDF]

Nanomicro Lett
Sun Z, Yu B, Dong C, Yu C, Sheng L, Cui Z, Liu Y, Lu Z, Chen B, Xie D, Huang Z, Zeng S, Ou Q.   +12 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Selective, Oxygen-Tunable, and Metal-Free Functionalization of Polyethylene Through Dual-Mode Nitrosation and Carbonylation. [PDF]

Angew Chem Int Ed Engl
Cluzeau L, Robert F, Bassani DM, Landais Y, Taton D.   +4 more
europepmc   +1 more source