Results 121 to 130 of about 14,062,695 (299)

Semi-Dual Attention: A Structure-Preserving Attention Mechanism Derived from Semi-Dual Optimization Theory

ITEGAM-JETIA
Since the introduction of the Transformer architecture, attention mechanisms have become a core component of sequence modeling and large-scale pre-trained models. However, almost all existing mainstream attention methods are based on a "primal" modeling
Jincheng Zhang, Rukthin Laoha, Potsirin Limpinan, Thada Jantakoon   +3 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Effect of dual-scale precipitates on the deformation behavior of AZ41 magnesium alloy via wire-arc directed energy deposition

Journal of Materials Research and Technology
With the need for energy saving and emission reduction, the process of wire arc directed energy deposition (WADED) of large-scale, high-precision Mg alloy parts is becoming more widely recognized.
Yuhang Du, Pubo Li, Hao Ning, Tianle Zou, Yongqiang Zhang, Bintao Wu   +5 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Dual inflation and bounce cosmologies interpretation of pulsar timing array data

Journal of High Energy Physics
We explore a dual scenario of generalized inflation and bounce cosmologies, producing a scale-invariant curvature perturbation spectrum. Bayesian analysis with pulsar timing array data identifies, for the first time, viable regions from inflation and ...
Changhong Li, Junrong Lai, Jinjie Xiang, Chaofan Wu   +3 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Supervised aerobic-strength exercise reduces postural sway and improves dual-task gait in Parkinson’s disease

Scientific Reports
Parkinson’s disease (PD) impairs balance and gait, increases fall risk, and reduces quality of life. While levodopa remains the primary treatment, it has limited effects on postural instability. Exercise training offers complementary benefits. This study
Pavol Martiš, Diana Bzdúšková, Zuzana Košutzká, Lucia Slobodová, Igor Straka, Karin Marček Malenovská, Oksana Mytiai, Veronika Tirpáková, Patrik Konrády, Viera Litváková, Martin Turi Nagy, Zuzana Urbančík, Peter Valkovič, Jozef Ukropec, Barbara Ukropcová, Jana Kimijanová   +15 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source