Results 101 to 110 of about 989,935 (262)
TerroryzmMost of biological warfare agents are simultaneously serious biological threats for public health. The way in which these factors are used is mainly determined by the anthropogenic factor. Accelerated
Anna Bielecka-Oder
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Use and dual use of synthetic biology
Comptes Rendus. BiologiesA brief history of the field shows that the impression of novelty we have today when we talk about synthetic biology is merely the sign of a rapid loss of memory of the events surrounding its creation. The dangers of misuse were identified even before the first experiments, but this has not led to a shared awareness.
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Dual-use return-water irrigation system
California Agriculture, 1967 This study indicates that where tail water is a necessity to provide an appreciable increase in production of a relatively high-value crop, a large investment in the irrigation return-water system can still be economically feasible.
F Aljibury, J Brown, C Houston
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Annals: Series on Military Sciences, 2010 One characteristic of today's society is the existence of dynamic structures with rapid transformations with constant character, for which the necessary time for making decisions has been enormously compressed, the succession turning into simultaneity.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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