Results 51 to 60 of about 989,935 (262)

Dual Use Libraries: Guidelines for Success [PDF]

Library Trends, 2006
Combined school and public libraries have been studied extensively for more than thirty years. Common advantages and disadvantages, together with typical problems, have been identifi;ed. From the work of researchers in three countries, predictors of success can be articulated: the population served is less than 10,000; a formal planning process ...
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The EU’s dual-use export control and human rights risks: the case of cyber surveillance technology

Europe and the World, 2019
Export of cyber technology can undermine human rights in countries of destination. In the aftermath of the Arab Spring, political controversies have arisen around EU-exported cyber surveillance technology, which allegedly helped autocratic states ...
doaj   +2 more sources

Development of Dual-Use Hemorrhage Control Methods: a Review of Solutions and a Future Directionfor Civilian and Military Applications [PDF]

Military Technology and Science
The article presents a review of the latest advancements in hemorrhage control, a crucial aspect of both military and civilianemergency medicine (dual-use).
Nikoletta Buczek, Michał Antczak, Anna Czubowicz, Maciej Wiewiór, Denis Ivanov   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Applicability of International Humanitarian Law to Cyber Operations: A Review of Russian and Western Approaches

Vestnik RUDN. International Relations
The relevance of this study stems from the fact that cyber operations have become an integral element of contemporary armed conflicts, while the applicability of international humanitarian law (IHL) to the digital environment remains contested and is ...
Vadim B. Kozyulin
doaj   +1 more source

Analysis of the Prospects for the Development of Dual-Use Technologies in PolandBased on the Example of Unmanned Aerial Vehicles [PDF]

Military Technology and Science
The publication presents an analysis of the prospects for the development of the unmanned aerial vehicle (UAV) market inPoland as a dual-use technology.
Rafał Parczewski
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Drivers and Prospects for the Italian Economic Pivot in the Indo-Pacific

Italian Political Science
What shapes Italy’s approach to the Indo-Pacific? This study analyses Italy’s current and emerging engagement with the Indo-Pacific region through the lens of trade, recognizing the area's growing geopolitical and geoeconomic significance.
Alessandro Vesprini, Matteo Piasentini
doaj   +4 more sources