Results 101 to 110 of about 1,966,012 (318)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

DUAL IN ŠIMUN KOŽIČIĆ BENJA’S MISAL HRUACKI

open access: yesFluminensia: Journal for Philological Research, 2012
The particularity of language present in the books printed in Šimun Kožičić Benja’s Glagolitic printing house in Rijeka has already been noticed in the literature.
Ivana Eterović, Blanka Ceković
doaj  

Dual Drug Loaded Lipid Nanocarrier Formulations for Topical Ocular Applications

open access: yesInternational Journal of Nanomedicine, 2022
Ahmed Adel Ali Youssef,1,2 Narendar Dudhipala,2 Soumyajit Majumdar2,3 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt; 2Department of Pharmaceutics and Drug Delivery, School of Pharmacy ...
Youssef AAA, Dudhipala N, Majumdar S
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

DVOJINA U JEZIKU TEKSTOVA HRVATSKOGLAGOLJIČKE NELITURGIJSKE KNJIŽEVNOSTI XV. STOLJEĆA

open access: yesRasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 1999
Članak je posvećen opisu i problemima funkcioniranja dvojine kao elementa gramatičke kategorije broja u jeziku Petrisova zbornika (1468), najznačajnijega kodeksa glagoljaške neliturgijske književnosti XV. stoljeća.
Eduard Hercigonja
doaj  

Un enfoque epistemológico para enseñar el concepto de energía en mecánica en cursos de Física Introductoria

open access: yesRevista Eureka sobre Enseñanza y Divulgación de las Ciencias
La energía es un concepto fundamental que permite la explicación y predicción de fenómenos en todos los campos de la física. Esto puede explicar que su comprensión se haya convertido en un objetivo de aprendizaje prioritario en los currículos de ciencias
Nicolás Gandolfo   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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