Results 161 to 170 of about 12,700 (294)

Sustainability in Healthcare: The Role of Digital Technologies for Improving Patient Engagement

open access: yesBusiness Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT Sustainability in healthcare is getting considerable research attention as systems worldwide tend to balance environmental, social, and economic factors. In this context, digital technologies have demonstrated significant potential to enhance engagement among different consumer groups across various industries.
Francesco Schiavone   +4 more
wiley   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

open access: yesBrain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga   +11 more
wiley   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

open access: yesBritish Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva   +10 more
wiley   +1 more source

SMURF1 Regulates CTCF‐HOXA10 Axis and Promotes Tumor Progression in Nasopharyngeal Carcinoma

open access: yesCancer Science, EarlyView.
Our study showed that SMURF1 was significantly upregulated in nasopharyngeal carcinoma (NPC) and promoted tumor progression and SMURF1 promoted K48‐linked ubiquitination degradation of CTCF. ABSTRACT The aberrant upregulation of Homeobox A10 (HOXA10) has been implicated in the progression of nasopharyngeal carcinoma (NPC), but the mechanisms driving ...
Ying Jin   +5 more
wiley   +1 more source

Reduction of DC-link Capacitor in Case of Cascade Multilevel Converters by means of Reactive Power Control [PDF]

open access: yes, 2014
Blaabjerg, Frede   +5 more
core   +1 more source

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