Results 81 to 90 of about 12,700 (294)

Bidirectional DC-DC Converter Topologies for Low-Voltage Battery Interface: Comparative Assessment [PDF]

, 2018
The growing interest towards efficient and reliable bidirectional DC-DC converter topologies for interfacing low-voltage (LV) batteries, eg. 48 V, with a high-voltage (HV) DC-link, eg.
Ahmed Abdelhakim, G. Spiazzi, P. Mattavelli, PISTOLLATO, SIMONE   +3 more
core   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Modeling and Control Gain Design Method for Dual Active Bridge Converter With Dual-Phase-Shift Modulation

IEEE Access
The Dual Active Bridge (DAB) converter offers several advantages, including high power conversion efficiency and improved safety by providing galvanic isolation between the input and output through the use of a high-frequency transformer and H-bridge ...
Tae-Hyeon Lim, Jin-Su Jang, Gi-Young Lee
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Analysis tool for initial high level assessment of candidate MEA architectures [PDF]

, 2016
Mass and efficiency are key performance indicators for the development and design of future electric power systems (EPS) for more-electric aircraft (MEA).
Burt, Graeme, Jones, Catherine, Norman, Patrick, Telford, Rory   +3 more
core   +1 more source

TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis

Advanced Science, EarlyView.
This study shows TGM2 is upregulated in AP, impairing macrophage efferocytosis by inhibiting the STAT6–GAS6 axis. The lactoferrin‐modified, ROS‐responsive LF‐LNP@si‐TGM2 targets pancreatic macrophages, silences TGM2, restores the axis, and alleviates AP.
Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue   +8 more
wiley   +1 more source

Coordinated Control of Energy Storage in Networked Microgrids under Unpredicted Load Demands

, 2018
In this paper a nonlinear control design for power balancing in networked microgrids using energy storage devices is presented. Each microgrid is considered to be interfaced to the distribution feeder though a solid-state transformer (SST).
Chakrabortty, Aranya, Cisneros, Rafael, Husain, Iqbal, Khan, Md Tanvir Arafat   +3 more
core   +1 more source

Switching frequency optimization for a Solid State Transformer with Energy Storage Capabilities [PDF]

, 2016
Energy Conversion Congress and Exposition (ECCE), 2016 IEEE (2016.
García Fernández, Pablo, García García, Jorge, Navarro Rodríguez, Ángel, Saeed Hazkial Gerges, Sarah, Schneider, Hannes   +4 more
core   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Solid-State Transformers for Interfacing Solar Panels to the Power Grid: An Optimum Design Methodology of a High Frequency Transformer for dc-dc Converter Applications [PDF]

, 2016
Nowadays the use of power electronic interfaces to integrate distributed generation with the power grid is becoming relevant due to the increased penetration of renewable energy sources like solar, and the continued ...
George, Kenny
core   +2 more sources