Results 81 to 90 of about 2,961 (282)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

T-Type-Based Dual-Active-Bridge DC-DC Converter With Voltage Balancing Capability for Bipolar DC Distribution System

IEEE Access
A dual-active-bridge (DAB) converter has been widely used to construct the dc bus voltage of a dc distribution system. However, in the case of a bipolar dc system, conventional DAB converters fail to regulate the bipolar dc bus voltage levels due to the ...
Jun Young Lee, Jun-Suk Lee, Jee-Hoon Jung   +2 more
doaj   +1 more source

?????? ????????? ??????????????? ????????? ?????? Dual Active Bridge ???????????? ????????? ???????????? ????????? ????????? ????????? ?????? ??????

, 2017
??? ??????????????? ????????? ????????? ???????????? ???????????? Dual Active Bridge (DAB) ???????????? ?????? ????????? ???????????? ??? ????????? ?????? ???????????? ????????? ???????????? ?????? ???????????? ?????? ??????????????? ???????????? ?????? ?
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core  

A novel matrix converter based resonant dual active bridge for V2G applications

, 2012
Dual-active bridges (DABs) can be used to deliver isolated and bidirectional power to electric vehicles (EVs) or to the grid in vehicle-to-grid (V2G) applications.
Twiname, R., Vilathgamuwa, D. Mahinda, Madawala, Udaya K., Thrimawithana, Duleepa J.   +3 more
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

An Active Power Decoupling Method for Single Phase DC/AC DAB Converters

IEEE Access, 2019
The existence of the double grid frequency (100 Hz) ripple current in dc/ac dual active bridge (DAB) power converters can degrade their performance and as such these ripples need to be compensated.
Jiang You, D. Mahinda Vilathgamuwa, Negareh Ghasemi, Wynand Louis Malan   +3 more
doaj   +1 more source

Synthetic Strategies for Activity-Based Probes to Decode Ubiquitin-Like Modifiers. [PDF]

Chemistry
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Chanda S, Pham A, Karnati S, Rodriguez NS, Toner A, Liu WR.   +5 more
europepmc   +2 more sources

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Implementation of Single-Phase Shift (SPS) and Extended Phase Shift (EPS) for Dual Active Bridge (DAB)

Indian Journal Of Science And Technology
Objectives: To improve power transfer and efficiency in Dual Active Bridge (DAB) converters, this study compares and assesses the Single-Phase Shift (SPS) and Extended Phase Shift (EPS) control techniques. Methods: Using the Dual Active Bridge (DAB) arrangement, the research focuses on implementing SPS and EPS control methods to an Isolated ...
Vivek Kumar Tiwari, Mohammed Asim, M D Aftab Alam, Mohd Imran Siddiqui, M A Alam   +4 more
openaire   +2 more sources

Comparative evaluation of bidirectional dual active bridge DC-DC converter variants

, 2016
For the realization of DC-DC converters in automotive industry, the Dual Active Bridge (DAB) converter seems to be a promising choice because of its soft-switching and high-power-density capability.
Huisman, H.; id_orcid, Lomonova, E.A., Huisman, H., Jordi Everts, Henk Huisman, Sfakianakis, G., Everts, J., Georgios E. Sfakianakis, Elena A. Lomonova, Lomonova, E.A.; id_orcid   +9 more
core   +1 more source