Results 221 to 230 of about 60,798 (279)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Efficient synthesis, dual anti-tubercular and antioxidant activity of triazole-acetophenone derivatives: enhanced efficacy <i>via</i> esterification and quantum mechanical validation of CYP121 binding. [PDF]

RSC Adv
Jagtap RA, Jagdale BS, Dhonnar SL, Shaikh SA, More RA, Alavala RR, Muteeb G, Fernandez-Conde D, Pawar TJ, Meshram RJ, Escobar-Cabrera J, Chobe SS.   +11 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Structural Exploration and Expected values of Topological Indices of Square-Hexagonal <i>T</i> _2,3 Kink Chains for Advanced Engineering Applications. [PDF]

ACS Omega
Kanwal S, Khalil M, Razzaque A.
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

A Hybrid In Silico Approach for Identifying Dual VEGFR/RAS Inhibitors as Potential Anticancer and Anti-Angiogenic Agents. [PDF]

Pharmaceuticals (Basel)
Bono A, La Monica G, Alamia F, Tocco D, Lauria A, Martorana A.   +5 more
europepmc   +1 more source

Machine learning guided virtual screening of FDA approved drugs targeting GSK-3β in Alzheimer's disease. [PDF]

Sci Rep
Kumar BS, Dinesh BGH, Ganjipete S, Ramar M, Ammunje DN, Kunjiappan S, Chidambaram K, Pavadai P.   +7 more
europepmc   +1 more source

Selectivity trends in two-electron oxygen reduction: insights from two-dimensional materials. [PDF]

Chem Sci
Siahrostami S.
europepmc   +1 more source

Machine Learning-Guided Design of Rhenium Tricarbonyl Complexes for Next-Generation Antibiotics. [PDF]

ACS Bio Med Chem Au
Nedyalkova M, Demirci G, Cortat Y, Schindler K, Rahmani F, Horner J, Vasighi M, Crochet A, Pavic A, Mamula O, Zobi F, Lattuada M.   +11 more
europepmc   +1 more source

A Multi-input Deep Learning Architecture for STAT3 Inhibitor Prediction. [PDF]

ACS Omega
Liang K, Qin W, Zhang Y.
europepmc   +1 more source