Results 81 to 90 of about 974,940 (289)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Leather surface defect inspection using a binary descriptor and dual channel transformer

Discover Computing
The inspection of surface defects in leather manufacture has attracted considerable attention due to the significant impact of appearance on leather pricing.
Shanjiang Zhang, Jian Lian, Renjing Liu
doaj   +1 more source

Machine learning driven rational design of dual atom catalysts on graphene for carbon dioxide electroreduction

Nano Research
The development of high-performance atomic catalysts for the carbon dioxide reduction reaction (CO2RR) is a time-consuming process due to the complexity of the reaction mechanism and the uncertainty of the active site.
Dongxu Jiao, Xinyi Li, Mingzi Sun, Lin Liu, Jinchang Fan, Jingxiang Zhao, Bolong Huang, Xiaoqiang Cui   +7 more
doaj   +1 more source

Dual-Descriptor Tailoring: The Hydroxyl Adsorption Energy-Dependent Hydrogen Evolution Kinetics of High-Valance State Doped Ni₃N in Alkaline Media

, 2019
The requirement of both water discharge and hydrogen adsorption free energy restricts the activity of most electrocatalysts for hydrogen evolution reaction (HER) in alkaline medium.
Bao Zhang (186933), Ling Miao (1533910), Jia Liu (41593), Lishang Zhang (7393019), Houzhao Wan (1559590), Jinsong Wang (444608), Jianjun Jiang (395680)   +6 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Chemometrics for flavor science: Mapping structure–perception relationships using PCA and Fuzzy C-Means

Digital Chemical Engineering
This work investigates the proposition that flavor descriptors are systematically rooted in reproducible chemical features and that combinations of functional groups explain the overlap and multiplicity of sensory perceptions.
L.P. Queiroz, P. Lima, R.W.S. Pessoa, H. Martens, I.B.R. Nogueira, A.M. Ribeiro   +5 more
doaj   +1 more source

The Optimal Linear Quadratic Feedback State Regulator Problem for Index One Descriptor Systems [PDF]

In this note we present both necessary and sufficient conditions for the existence of a linear static state feedback controller if the system is described by an index one descriptor system. A priori no definiteness restrictions are made w.r.t.
Salmah, Y., Wijayanti, I.E., Engwerda, J.C.   +2 more
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Safe-by-redesign guidance for toxic industrial chemicals using explainable artificial intelligence: Introducing the DETOX-QSAR model

Scientific Reports
Toxic industrial chemicals (TICs) are dual-use agents with potential for immediate and lethal inhalation toxicity upon exposure. This study first introduced the Descriptor-Engineered Transition to Non-Toxicity via QSAR (DETOX-QSAR) model, a tool for ...
Feyza Kelleci̇ Çeli̇k, Seyyide Doğan
doaj   +1 more source

Why local hyper-softness is a more appropriate local reactivity descriptor than dual descriptor and Fukui function?

, 2023
Abstract In this paper, the reason why local hyper-softness (LHS) allows to make comparisons of local reactivities among molecular systems of similar or different sizes as scientific literature has evidenced in the last ten years is analyzed. This lies on the fact that LHS is an intensive property.
openaire   +1 more source