Results 101 to 110 of about 211,702 (296)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

PERSISTENCE OF THE GENDER WAGE GAP: THE ROLE OF THE INTERGENERATIONAL TRANSMISSION OF PREFERENCES [PDF]

This paper provides an explanation of the evolution and persistence of the gender wage gap due to differences in training within the framework of an overlapping generations model with intergenerational transmission of preferences.
Luisa Escriche
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Comparative Performance Analysis of Dual-Prime RSA and Eight-Prime RSA

Journal of Information Systems and Informatics
This study presents a comparative performance analysis of Dual-Prime RSA and Eight-Prime RSA by evaluating computational efficiency in key generation, encryption, and decryption at 1024-bit and 2048-bit key lengths.
Rahmat Sulaiman, Agustina Mardeka Raya, Djoko Soetarno, Tri Sugihartono, Ellya Helmud   +4 more
doaj   +1 more source

Privacy-aware EV charging-station assignment: QoS–fairness optimization with traffic-analysis resistance [PDF]

PeerJ Computer Science
The assignment of charging stations (CS) within urban electric vehicle (EV) networks necessitated a careful equilibrium among user quality of service (QoS), equitable station load distribution, and the mitigation of traffic-analysis inference from ...
Akram Y. Sarhan, Mahdi Jemmali, Bouziane Brik, Ameen Banjar   +3 more
doaj   +2 more sources

Bridging the Gap: A Dual-Perspective Analysis of Audio-Visual Material Integration in Indonesian EFL Speaking Classrooms

Journal of General Education and Humanities
The integration of English audio-visual (AV) materials has been widely promoted as an effective approach for enhancing speaking skills in English as a Foreign Language (EFL) contexts; however, a persistent gap remains between its theoretical potential and classroom implementation in Indonesia. This qualitative case study aims to investigate perceptions
Fikra Afdhali, Utami Dewi, Farida Repelita Waty BR Kembaren   +2 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Primal-dual variable neighborhood search for the simple plant-location problem

, 2007
Copyright @ 2007 INFORMSThe variable neighborhood search metaheuristic is applied to the primal simple plant-location problem and to a reduced dual obtained by exploiting the complementary slackness conditions.
Brimberg, J, Hansen, P, Urosevic, D, Mladenović, N   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source