Results 111 to 120 of about 10,110,773 (226)

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

On Dual Number of z-Stems in the Mycenaean Tablets [PDF]

, 1983
A detailed examination of the tablets and of the direct and inverse indexes, carried out with the intention —now discarded— of making up an exhaustive grammatical index, led me to six tablets showing eleven possible examples of nominative-acusative dual ...
Moralejo, Juan José
core  

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Lactate Homeostasis Disruption Potentiates TACE‐Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Lactate homeostasis is disrupted through spatially coordinated extracellular neutralization and intracellular acidification, triggering calcium overload, mitochondrial dysfunction, and immunogenic cell death. This metabolic reprogramming alleviates the immunosuppressive tumor microenvironment and enhances immune checkpoint blockade, providing a ...
Minjiang Chen, Xiaoxiao Chen, Baozhu Yang, Hui Xu, Xueting Sun, Hongkai Qi, Huilin Hu, Ronghua Wu, Fengkai Qiu, Bing Wu, Yu Luo, Gaofeng Shu, Jiansong Ji   +12 more
wiley   +1 more source

Lexical and grammatical meaning’s ambiguity in the job creation law number 6 of 2023 [PDF]

Job Creation Law Number 6 of 2023 was designed to revise and replace Job Creation Law Number 4 of 2022, which had previously replaced Job Creation Law Number 11 of 2020.
Datang, Frans Asisi, Purwono, Prahoro Yudo   +1 more
core  

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

Living Electronics: Microbial Metabolism as Batteries, Resistors, and Capacitors

Advanced Electronic Materials, EarlyView.
Three microorganisms are assigned the three elementary roles of a circuit on one sheet of paper. Dormant Bacillus subtilis spores germinate to switch the power source on; a photosynthetic Synechocystis biofilm sets resistance by the color and intensity of light; and a respiring Shewanella oneidensis biofilm stores charge. Together they form a printable
Botian Wang, Ruohan Zhang, Seokheun Choi
wiley   +1 more source

Improving Post‐Fall Assessment Documentation in Older Inpatients Using a Structured Falls Proforma: A Retrospective Cohort Study

AGING MEDICINE, EarlyView.
Falls among hospital inpatients are associated with significant morbidity and require comprehensive post‐fall assessment. This retrospective cohort study evaluated documentation completeness following inpatient falls in older adults and compared assessments completed using a structured Falls Proforma with standard documentation methods.
Ella V. Brockwell‐Mole, Dujinthan Jayabalan, Su Kitchen, Minoti Bhagat   +3 more
wiley   +1 more source

Stochastic Locomotion Emerging From Body–Environment Interactions in a Mexican Jumping Bean–Inspired Robot

Advanced Intelligent Systems, EarlyView.
Inspired by the Mexican jumping bean, this study presents a centimeter‐scale, electronics‐free robot that merges principles from both the animal and plant kingdoms. A thermo‐responsive actuator mimicking larval motion, enclosed within a uniquely shaped plant‐seed‐inspired shell, generates jumping, rolling, flipping, sliding, and climbing through ...
Ragesh Chellattoan, Alessio Mondini, Edoardo Sinibaldi, Barbara Mazzolai   +3 more
wiley   +1 more source