Results 141 to 150 of about 108,525 (234)

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño   +4 more
wiley   +1 more source

A Systematic Review and Model‐Based Meta‐Analysis of Pegylated‐Interferon‐α‐Induced HBsAg Loss in Chronic Hepatitis B Virus Infection

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pegylated‐interferon‐α (Peg‐IFNα) is a treatment option for chronic hepatitis B virus (HBV) infection. To quantify treatment response variability, we conducted a model‐based meta‐analysis (MBMA) of hepatitis B surface antigen (HBsAg) loss, defined as a binary outcome based on HBsAg levels falling below the limit of detection, with Peg‐IFNα ...
Nathan J. Hanan   +10 more
wiley   +1 more source

Establishing a Model for Serious Science Game Design for Elementary Learners: A Longitudinal, Mixed Methods Study of Serious Game Design Mechanics That Facilitate Science Learning

open access: yesScience Education, EarlyView.
ABSTRACT Immersive learning environments, such as serious educational games (SEGs), offer promising opportunities for enhancing elementary students' science learning outcomes and fostering their interest in science. These environments allow learners to explore scientific phenomena in ways traditional instruction cannot replicate.
Georgia W. Hodges, Kayla Flanagan
wiley   +1 more source

Introduction [PDF]

open access: yes, 1991
Zaefferer, Dietmar, Zaefferer, Dietmar
core  

Sustainable Schools: Changing Society Towards Sustainability

open access: yesSustainable Development, EarlyView.
ABSTRACT A change in mindset has taken place in educational institutions, characterised by a growing awareness of sustainability and environmental aspects. Inspired by the UNESCO Global Action Programme, various ministries have allowed to be certified as a School of Sustainability at different levels, albeit on a voluntary basis and without substantial
Monika Bauer, Gertrud E. Morlock
wiley   +1 more source

Dual-stage framework with soft-label distillation and spatial prompting for image-text retrieval. [PDF]

open access: yesPLoS One
Jin R   +9 more
europepmc   +1 more source

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