Results 11 to 20 of about 1,148,675 (153)

Discovery, Optimization, and Evaluation of Potent and Selective PI3Kδ‑γ Dual Inhibitors for the Treatment of B‑cell Malignancies

open access: yes, 2022
Nowadays, PI3Kδ-γ dual inhibitors have been approved for the treatment of B-cell malignancies. Dual inhibition of PI3Kδ and PI3Kγ represents a unique therapeutic opportunity and may confer greater benefits than either isoform inhibition alone in the ...
Lijuan Chen (150349)   +15 more
core   +3 more sources

Efficacy of Dual Cd19-Cd79B Car In B-Cell Malignancies [PDF]

open access: yes, 2022
Despite high clinical responses, about 30%-60% of patients with B-cell malignancies relapse following CD19-targeting chimeric antigen receptor (CAR) T cell therapy. CD19 loss is a major cause of relapse and resistance after CD19 CAR T therapy.
Cheng, Xiaoyun
core   +1 more source

Analytical and clinical characterization of an optimized dual monoclonal sandwich ELISA for the quantification of thymidine kinase 1 (TK1) protein in human blood samples.

open access: yesPLoS ONE, 2022
Thymidine Kinase 1 (TK1) plays an important role in DNA precursor synthesis and serum TK1 activity has been used as a biomarker for prognosis and therapy monitoring of different malignancies.
K K Jagarlamudi   +5 more
doaj   +2 more sources

Interpreting discordance on dual-tracer positron emission tomography–computed tomography in the setting of metastatic neuroendocrine tumor: Detection of metachronous triple-negative breast carcinoma

open access: yesWorld Journal of Nuclear Medicine, 2020
Second primary malignancies (SPMs) are known to be associated with neuroendocrine tumors (NETs). The association necessitates a careful assessment of the dual-tracer positron emission tomography–computed tomography (PET-CT) imaging findings to identify ...
Ashwini Kalshetty, Sandip Basu
doaj   +1 more source

Coexistence of Prefibrotic Myelofibrosis with Monoclonal Gammopathy of Undetermined Significance: A Case Report

open access: yesCase Reports in Oncology, 2021
The coexistence of dual hematological neoplasms is an unusual and challenging presentation due to the different combination of etiopathology. The presentation of synchronous dual hematological malignancies can be one of the 3 types: myeloid + lymphoid or
Omar M. Ismail   +4 more
doaj   +1 more source

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms [PDF]

open access: yes, 2009
Background: Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities,
Christiane Pott   +180 more
core   +2 more sources

Dermatological Malignancies at a University Teaching Hospital in north-western Tanzania: A Retrospective Review of 154 Cases [PDF]

open access: yes, 2012
Dermatological malignancies are among the most common form of cancers and the global incidence has been increasing at an alarming rate. A retrospective study was conducted to determine the prevalence, histopathological pattern, anatomical distribution ...
Kahima, Kahima J.   +6 more
core   +1 more source

A case of synchronous dual malignancy with the index malignancy in the lower alveolus and a second primary malignancy in the left breast

open access: yesJournal of Medical Evidence, 2020
Multiple primary malignancies are nowadays commonly detected due to better radiological techniques, greater awareness and an increase in number of elderly cancer survivors.
Satya Prakash Agarwal   +4 more
doaj   +1 more source

Impact of PWM strategies on RMS current of the DC-link Voltage Capacitor of a dual-three phase drive [PDF]

open access: yes, 2014
The major drawback of usual dual three-phase AC machines, when supplied by a Voltage Source Inverter (VSI), is the occurrence of extra harmonic currents which circulate in the stator windings causing additional losses and constraints on the power ...
ROUHANA, Najib   +5 more
core   +1 more source

What are multiple primary malignancies? [PDF]

open access: yes, 2017
Over the past 30 years, the incidence of cancer in Poland has more than doubled. Advances in technology, early diagnosis and improved treatment make more and more malignancies curable. An increase in the survival of cancer patients has also been observed.
Anna Doboszyńska   +3 more
core   +2 more sources

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