Results 221 to 230 of about 1,157,757 (252)

Barriers and Blueprints: Next-Generation Engineering Strategies for CAR-T Cell Therapy in Gastrointestinal Tumors. [PDF]

Pharmaceuticals (Basel)
Ismail M, Al-Gizey N, Alabed Z, Mustafa N, Al-Najjar E, Hamdaneh Y, Eid N, Esmail A.   +7 more
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Distal cholangiocarcinoma mimicking pancreatic ductal adenocarcinoma successfully converted to resection following PD-1/CTLA-4 bispecific immunotherapy (cadonilimab) combined with nab-paclitaxel-based chemotherapy: a case report providing preliminary real-world insight. [PDF]

Front Oncol
Li Y, Sheng X, Mi C, Du Y, Wang S, Wang D, Wang W, Wang L, Shi G, Wang M, Ma T, Xu X, Wang Y, Yang H.   +13 more
europepmc   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Functional genomics-guided design of CAR-T and CAR-NK therapies in hematological malignancies: aligning cellular engineering with immune escape and microenvironmental resistance. [PDF]

Front Genome Ed
Cai S, Tan Y, Yang Q, Huang J.
europepmc   +1 more source

Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics. [PDF]

Biomark Res
Deng R, Wang B, Zou M, Mao K, Shang J, Qiu J, Zhou J, Xu H, Ma X, Wang Y, Cai L, Gong K.   +11 more
europepmc   +1 more source

Association Between Melanoma and Hematologic Malignancies: Evidence From the NIH Precision Medicine Initiative. [PDF]

Pigment Cell Melanoma Res
Kumar M, Kooner A, Chauhan A, Sekhon RA.
europepmc   +1 more source

Overcoming fratricide of CD86 targeting CAR-T cells by defined logic-gate CAR strategy. [PDF]

Exp Hematol Oncol
Riet T, Lennartz S, Bösing N, Prinz LF, Dähn L, Scheid C, Hallek M, Chmielewski MM.   +7 more
europepmc   +1 more source

Durable response to dual immune checkpoint blockade in Lynch syndrome-associated serous ovarian carcinoma: a case report. [PDF]

Front Med (Lausanne)
Mourad M, Assaf N, Al Mahmasani L, Mahfouz R, Fakhruddin N, Shamseddine A.   +5 more
europepmc   +1 more source