Results 111 to 120 of about 776,276 (326)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Parabolic Numbers: A New Perspective
Journal of New TheoryThus far, many studies have been conducted on $p$-complex numbers. Depending on the sign of $p$, there are three cases: hyperbolic, dual, and elliptic. In the literature, dual numbers are called parabolic numbers, but they do not parameterize parabolas ...
Furkan Semih Dündar
doaj +1 more source
On Euclidean and Hermitian Self-Dual Cyclic Codes over $\mathbb{F}_{2^r}$ [PDF]
arXiv, 2016 Cyclic and self-dual codes are important classes of codes in coding theory. Jia, Ling and Xing \cite{Jia} as well as Kai and Zhu \cite{Kai} proved that Euclidean self-dual cyclic codes of length $n$ over $\mathbb{F}_q$ exist if and only if $n$ is even and $q=2^r$, where $r$ is any positive integer.
arxiv
The Duality of the Volumes and the Numbers of Vertices of Random Polytopes [PDF]
, 2023 Christian Buchta
openalex +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Review of theory and implementation of hyper-dual numbers for first and second order automatic differentiation [PDF]
arXiv, 2018 In this review we present hyper-dual numbers as a tool for the automatic differentiation of computer programs via operator overloading. We start with a motivational introduction into the ideas of algorithmic differentiation. Then we illuminate the concepts behind operator overloading and dual numbers.
arxiv
Some Duality Results on Linear Programming Problems with Symmetric Fuzzy Numbers [PDF]
, 2009 S. H. Nasseri, Nezam Mahdavi‐Amiri
openalex +1 more source
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Self-Dual and Complementary Dual Abelian Codes over Galois Rings [PDF]
arXiv, 2014 Self-dual and complementary dual cyclic/abelian codes over finite fields form important classes of linear codes that have been extensively studied due to their rich algebraic structures and wide applications. In this paper, abelian codes over Galois rings are studied in terms of the ideals in the group ring ${\rm GR}(p^r,s)[G]$, where $G$ is a finite ...
arxiv
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source