Results 141 to 150 of about 2,644,466 (335)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
COMPUTATION OF THE KÖTHE-TOEPLITZ DUAL OF SOME SETS OF SEQUENCES OF FUZZY NUMBERS
The main aim of the present paper is to compute the α–dual (or Köthe-Toeplitz dual) for some sets of sequences of fuzzy numbers defined using an Orlicz function. We also compute the α–dual of some sets of difference sequences of fuzzy numbers.Sequence of
HEMEN DUTTA, B. SURENDER REDDY
core
Hyper dual numbers and their properties
, 2020 Tez çalışmasında, ilk olarak çalışmanın temelini oluşturan hiper dual sayılar ile ilgili ayrıntılı bilgiler verilmiştir. Daha sonra oluşturulan bu içerik kullanılarak hiper dual vektörler tanıtılıp özellikleri ayrıntılı bir şekilde ele alınmıştır.Firstly,
Çil, Furkan
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
QUANTIFYING PLAN ROBUSTNESS WITH A SINGLE DOSE CALCULATION USING DUAL NUMBERS [PDF]
Maximilian Hofer, Antony Lomax, Ye Zhang
openalex +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Efficient Computation of Arbitrary-Order Directional Derivatives in Multiple Directions via Generalized Dual Numbers [PDF]
F. Peñuñuri +3 more
openalex +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source