Results 171 to 180 of about 369,263 (302)

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Metalens-Based Dual Light-Sheet Fluorescence Microscopy. [PDF]

Small Methods
Luo Y, Chang CC, Hsu HC, Huang BW, Vyas S, Tseng SJ, Chu CH, Tanaka T, Huang KY, Tsai DP.   +9 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Boundary conditions for exploiting the cooperation of <i>Aminobacter niigataensis</i> MSH1 with <i>Piscinibacter</i> sp. K169 to support 2,6-dichlorobenzamide biodegradation in sand filters for drinking water treatment: role of cell density and organic carbon. [PDF]

Appl Environ Microbiol
Du S, Wouters A, Glorieux M, van Lieshout L, Horemans B, Springael D.   +5 more
europepmc   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Coding-complete genome sequences of two hepatitis C virus genotype 5 variants including one assigned to putative subtype 5b. [PDF]

Microbiol Resour Announc
Murphy DG, Mouammine A, Lin L, Hu X, Carpenter M.   +4 more
europepmc   +1 more source

Dual Cartan numbers and pseudo‐null lines [PDF]

İskender Öztürk
openalex   +1 more source

ON THE DUALITY THEOREMS FOR THE BETTI NUMBERS OF TOPOLOGICAL MANIFOLDS [PDF]

, 1930
Solomon Lefschetz, William W. Flexner
openalex   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Case Report: Genomic insights and personalized treatment in dual primary esophageal squamous cell carcinoma and gastric adenocarcinoma. [PDF]

Front Oncol
Miao C, Guo Y, Yang H, Zhu S, Chen Y, Zhao W, Hu X.   +6 more
europepmc   +1 more source