Results 181 to 190 of about 4,249,593 (344)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Investigating the Occurrence of Viruses in Sweet Cherry in China and Developing Multiplex RT-PCR Assays for Their Detection. [PDF]

Plants (Basel)
Wang J, Kan Q, Xie Y, Li H, Yu S, Zhang W, Feng C, Ma M, Cheng Y.   +8 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Resolving inflammation: The impact of antiretroviral therapy on macrophage traffic in and out of the CNS. [PDF]

PLoS Pathog
Wallis ZK, Midkiff CC, Zhao M, Autissier P, Kim SO, Amadeck AQ, Wang Y, Jakubowski M, Burdo TH, Miller AD, Li Q, Alvarez X, Blair RV, Williams KC.   +13 more
europepmc   +1 more source

Jumping numbers and ordered tree structures on the dual graph [PDF]

, 2010
Eero Hyry, Tarmo Järvilehto
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Strong uniqueness of enhancements for the dual numbers: a case study [PDF]

Alberto Canonaco, Amnon Neeman, Paolo Stellari   +2 more
openalex   +1 more source

Dual Numbers for Algorithmic Differentiation

, 2019
"The cubic spline interpolation method, the Runge–Kutta method, and the Newton–Raphson method are extended to dual versions (developed in the context of dual numbers). This extension allows the calculation of the derivatives of complicated compositions of functions which are not necessarily defined by a closed form expression.
F. Peñuñuri, O. Carvente, M.A. Zambrano-Arjona, R. Peón, Carlos A. Cruz-Villar   +4 more
openaire   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Duplex ddPCR detection of lytA and piaB in Streptococcus pneumoniae from nasopharyngeal swabs. [PDF]

Sci Rep
Kallsberg A, Magnussen JH, Djuurhus A, Slotved HC, Magnussen MD, Gaini S, Krogfelt KA.   +6 more
europepmc   +1 more source