Results 201 to 210 of about 384,390 (264)

Combined single- and dual-energy CT workflow for dose calculation in radiotherapy. [PDF]

Acta Oncol
Sand H, Edmund J, Appelt A, Wohlfahrt P, Taasti VT, Poulsen LØ, Søndergaard J, Nielsen MS.   +7 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Comparison of two dual-energy CT-based methods for proton stopping-power ratio estimation in brain cancer patients with metal implants. [PDF]

Acta Oncol
Tarp IS, Taasti VT, Jensen MF, Muren LP, Jensen K.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Soil phosphate availability drives shifts between arbuscular mycorrhizal and ectomycorrhizal fungi in the dual mycorrhizal plant Quercus serrata. [PDF]

New Phytol
Ezawa T, Mizukami C, Cahyaningtyas A, Mukai M, Kitayama K.   +4 more
europepmc   +1 more source

The Divisor Codex: Dual Hilbert-Space Geometry of Natural Numbers with Multiplicative and Additive Structure

Nadia Hadj Sahraoui
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Clinical relevance of circulating tumor DNA in HER2-positive advanced gastric cancer: a collaborative study of a phase Ib trial of dual HER2 and PD-1 targeted therapy (Ni-High). [PDF]

Ther Adv Med Oncol
Osumi H, Wakatsuki T, Ooki A, Chin K, Shoji H, Ogura M, Nakayama I, Yamamoto N, Hirano H, Hara H, Minashi K, Shinozaki E, Kato K, Ishizuka N, Kitano S, Takeuchi K, Boku N, Yamaguchi K, Takahari D.   +18 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Body composition measures assessed by bioelectrical impedance analysis and dual-energy X-ray absorptiometry in a sample of Brazilian adults and older adults. [PDF]

Front Nutr
Wahrlich V, Ciafrino A, Chain A, Bossan FM, Baltar VT, Dos Anjos LA.   +5 more
europepmc   +1 more source