Results 41 to 50 of about 236,408 (305)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Hole expansion of dual phase steels [PDF]

WIT Transactions on The Built Environment, 2012
In this work, the stretch-flangeability of dual phase (DP) steels was investigated through the hole expansion (HE) tests for three DP980 steel sheet samples. In order to understand the effect of hole surface quality on the HE results, the specimens were prepared with three hole machining methods, namely, electrical discharge machining (EDM), punching ...
Xu Le, F. Barlat, M. G. Lee, K. S. Choi, X. Sun   +4 more
openaire   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

DEFORMATION RESPONSE OF DUAL PHASE STEEL IN STATIC AND DYNAMIC CONDITIONS [PDF]

Applied Engineering Letters, 2019
In this work, strength and plastic deformation effect of the dual phase steel are analysed in the static and dynamic conditions. Since the dual phase steel is extensively used in the outer body parts of the automotive vehicles, their dynamic strength and
M.R. Sunil Kumar, Eva Schmidova
doaj   +1 more source

Effect of Fatigue Crack Growth Rate on Varied Percentage of Martensite for Welded DP Steel [PDF]

, 2013
The objective of this investigation is to study the fatigue behaviour of Dual phase(DP)steel with varying percentage of martensite. The study is conducted on samples of welded Dual phase steel prepared by intercritical ...
Kempaiah, U.N., Nagaraj Kori, .
core  

The status of GEO 600 [PDF]

, 2004
The GEO 600 laser interferometer with 600m armlength is part of a worldwide network of gravitational wave detectors. GEO 600 is unique in having advanced multiple pendulum suspensions with a monolithic last stage and in employing a signal recycled ...
Allen, B., Aufmuth, P., Aulbert, C., Babak, S., Balasubramanian, R., Barr, B.W., Berukoff, S., Bunkowski, A., Cagnoli, Gianpietro, Cantley, C.A., Casey, M.M., Chelkowski, S., Churches, D., Cokelaer, T., Colacino, C.N., Crooks, David R., Cutler, C., Danzmann, Karsten, Davies, R., Dupuis, Rejean J., Elliffe, E., Fallnich, Carsten, Franzen, A., Freise, A., Gossler, S., Grant, A., Grote, H., Grunewald, S., Harms, J., Heinzel, Gerhard, Heng, Ik S., Hepstonstall, A., Heurs, Michèle, Hewitson, M., Hild, S., Hough, James, Hough, James, Huttner, S.H., Itoh, Y., Jones, R., Kawabe, K., Killow, Christian, Koetter, K., Krishnan, B., Leonhardt, V., Lück, Harald, Machenschalk, B., Malec, M., Mercer, R.A., Messenger, Christopher, Mohanty, S., Mossavi, Kasem, Mukherjee, S., Murray, P., Nagano, S., Newton, G.P., Papa, M.A., Perreur-Lloyd, M., Pitkin, M., Plissi, M.V., Quetschke, V., Re, Virginia, Reid, S., Ribichini, L., Robertson, D.I., Robertson, Norna A., Romano, J.D., Rowan, Sheila, Ruediger, Albrecht, Sanders, Gary H., Sathyaprakash, Bangalore S., Schilling, R., Schnabel, R., Schutz, B.F., Seifert, F., Sintes, A.M., Smith, J.R., Sneddon, Peter H., Strain, Kenneth A., Taylor, I., Taylor, R., Thuering, A., Ungarelli, Carlo, Vahlbruch, H., Vecchio, Alberto, Veitch, J., Ward, Harry, Weiland, U., Welling, Herbert, Williams, P., Willke, Benno, Winkler, Walter, Woan, Graham, Zawischa, Ivo   +93 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Prediction of springback in the forming of advanced high strength steel: simulation and experimental study [PDF]

, 2011
Dual Phase (DP) steel is categorized as advanced high-strength steels (AHSS) which has tensile strengths ranging from 500 to 800 MPa. DP steel is gaining popularity in automotive applications.
Mohamad Noor, Noraishah
core  

A fabrication history based strain-fatigue model for prediction of crack initiation in a radial loading wheel [PDF]

, 2017
A strain-based fatigue model concerning fabrication history is applied to predict the fatigue life of a commercial car wheel under radial loads. As the prior conditions, the strain fatigue testing is performed on standard specimen of DP590 and FB540 ...
Gu, H.R, Ling, Y.C, Liu, Y.G., Ma, M.T., Qin, R., Wan, X.M, Wang, G.Y, Zhao, Y.   +7 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source