Results 61 to 70 of about 265,109 (310)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Effect of Quenching in Dual-phase Region on Microstructure and Mechanical Properties of 7Ni Steel
Cailiao gongcheng, 2018 The influence of quenching temperature and holding time in dual-phase region on microstructure and mechanical properties of 7Ni steel was studied by X-ray diffractometer, scanning electron microscopy and thermal dilatometer.
XU Li-xiong, WU Hui-bin, MOU Dan
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Tailoring dual-phase steel properties through controlled temperature and holding time during heat treatment [PDF]
MATEC Web of ConferencesThis study investigates the effect of controlled temperature and holding time on the microstructure and properties of DP600 dual-phase steel. Low-carbon steel (0.3 wt%C) was heat-treated at 850°C with holding times of 20, 40, 60, and 80 minutes, followed
Olorundaisi Emmanuel, Olubambi Peter A.
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Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Determining the influence of material solutions on durability and tare mass of light car trailers [PDF]
Transport Problems, 2010 The modern light trailers constructions are expected to have considerable safety level, guaranteed by the high construction durability as well as possible low mass.
Maciej BOLDYS
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Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Strength and Fracture Behaviour of Dual Phase Steel Dp450 in Static and Dynamic Conditions
Communications, 2019 In this work, strength and plastic deformation effect of the dual phase steel are analysed in the static and dynamic conditions. Since the dual phase steel is extensively used in the outer body parts of the automotive vehicles, its dynamic strength and ...
Sunil Kumar Meluru Ramesha +1 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Teshugang, 2007 The plane-strain compression test with strain rate 10 s-1 and 50 s-1 at 900~1200 ℃ for forged dual phase stainless steel 00Cr22Ni5Mo3N has been carried out by Gleeble 3800 simulation test machine.Test results showed that with increasing deformation ...
毛伟强 +6 more
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