Results 71 to 80 of about 265,109 (310)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Effect of Cr and Mo on σ- Phase Precipitation Behavior and Pitting Corrosion Resistance Properties of Ultra-Low-Carbon Dual Phase Stainless Steel

Teshugang, 2015
The σ-phase precipitation rule in four kinds of typical ultra-low-carbon dual phase stainless steel 00Cr21Ni2Mn5N, 00Cr22Ni5Mo3N, 00Cr25Ni7Mo3N and 00Cr27Ni7Mo5N solid-solution-treaded at 1 050 ~ 1 120 °C and aged at 500 ~ 1 100 °C and the effect of σ ...
李惠, 宋志刚, 丰涵, 郑文杰, 张颖   +4 more
doaj  

Dual Phase Ferrite-Martensitic Steel Micro-Alloyed with V-Nb [PDF]

Metalurgija, 2007
For low-carbon V-Nb micro-alloyed steel, dual phase ferrite-martensitic microstructures were prepared with a variable martensite fraction, which ranged from Vm 20 to 88%.
Džupon, M., Parilák, Ľ., Kollárová, M., Sinaiová, I.   +3 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Optimal control of multiphase steel production

Journal of Mathematics in Industry, 2019
An optimal control problem for the production of multiphase steel is investigated that takes into account phase transformations in the steel slab. The state equations are a semilinear heat equation coupled with an ordinary differential equation, that ...
Dietmar Hömberg, Klaus Krumbiegel, Nataliya Togobytska   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Constitutive model and dynamic deformation behavior of 800 MPa grade cold-rolled dual phase steel

工程科学学报, 2016
The Hopkinson experiment system was used to do the dynamic tensile experiment of 800 MPa grade cold rolled dual phase steel (DP800). The strain rate was determined as 500, 1000 and 2250 s-1 By comparing the experimental results, both the yield strength ...
CAI Heng-jun, HU Jing-fan, SONG Ren-bo, DAI Qi-feng   +3 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Hot Deformation Behavior of Dual Phase Stainless Steel 00Cr21Ni2Mn5N

Teshugang, 2008
The hot deformation behavior and structure evolution of austenite-ferrite dual phase stainless steel 00Cr21Ni2Mn5N with strain rate 5 - 50 s-1reduction ratio 60% at 850 ~ 1 150 ℃ have been studied by using Gleeble- 3800 thermo-mechanical simulator etc ...
郭海生, 宋志刚, 郑文杰, 周芸, 郭志鹏   +4 more
doaj