Results 41 to 50 of about 237,627 (302)

Synchrotron strain scanning for residual stress measurement in cold-drawn steel rods [PDF]

, 2011
Cold-drawn steel rods and wires retain significant residual stresses as a consequence of the manufacturing process. These residual stresses are known to be detrimental for the mechanical properties of the wires and their durability in aggressive ...
ISO (International Organization for Standardardization), J M Atienza, J Ruiz-Hervias, Llorca J., M Elices, Ruiz-Hervias J., Ruiz-Hervias J., Taleff E. M.   +7 more
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Hole expansion of dual phase steels [PDF]

WIT Transactions on The Built Environment, 2012
In this work, the stretch-flangeability of dual phase (DP) steels was investigated through the hole expansion (HE) tests for three DP980 steel sheet samples. In order to understand the effect of hole surface quality on the HE results, the specimens were prepared with three hole machining methods, namely, electrical discharge machining (EDM), punching ...
Xu Le, F. Barlat, M. G. Lee, K. S. Choi, X. Sun   +4 more
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

A fabrication history based strain-fatigue model for prediction of crack initiation in a radial loading wheel [PDF]

, 2017
A strain-based fatigue model concerning fabrication history is applied to predict the fatigue life of a commercial car wheel under radial loads. As the prior conditions, the strain fatigue testing is performed on standard specimen of DP590 and FB540 ...
Gu, H.R, Ling, Y.C, Liu, Y.G., Ma, M.T., Qin, R., Wan, X.M, Wang, G.Y, Zhao, Y.   +7 more
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Effect of Fatigue Crack Growth Rate on Varied Percentage of Martensite for Welded DP Steel [PDF]

, 2013
The objective of this investigation is to study the fatigue behaviour of Dual phase(DP)steel with varying percentage of martensite. The study is conducted on samples of welded Dual phase steel prepared by intercritical ...
Kempaiah, U.N., Nagaraj Kori, .
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Dry Sliding wear behaviour of Ferrite-Martensite Dual Phase Steels [PDF]

, 2013
In the present investigation, High Strength Low Alloy Steel (HSLA) was subjected to Intermediate Quench (IQ) heat treatment process at four different intercritical temperatures to obtain Dual Phase(DP) steels of varying percentages of ferrite-martensite ...
Aprameyan, S., Kempaiah, U.N.
core  

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source