Results 111 to 120 of about 150,972 (303)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Promoting and maintaining health of people with sight loss: A scoping study [PDF]
, 2009 This study was undertaken in response to a request by the Thomas Pocklington Trust to identify and explore the following issues: • The needs and concerns regarding immediate risks to health and safety related to sight loss; • Additional risks arising ...
Cattan, M +4 more
core
Cognitive impairment in Parkinson's disease : is it a unified phenomenon? [PDF]
, 2005 Parkinson's disease (PD) has long been associated with dementia. This has been found to correlate with participant age, age at onset of PD and severity of PD.
Brendel, Bettina +2 more
core +1 more source
Современная зарубежная психологияThis review provides an overview of the challenges of identifying dual sensory impairment in children with congenital disabilities. The concept of deafblindness and the special needs of the group with hearing and visual impairments are ...
A.Y. Khokhlova, C. Moreau
doaj +1 more source
A brief guide to carrying out research about adult social care services for visually impaired people [PDF]
, 2011 Carrying out research about adult social care services for visually impaired people presents challenges that are not necessarily found in other fields.
Charles, Nigel
core
Common visual problems in children with disability [PDF]
, 2014 Children with disability are at a substantially higher risk of visual impairment (VI) (10.5% compared with 0.16%) but also of ocular disorders of all types, including refractive errors and strabismus.
Salt, A, Sargent, J
core +2 more sources
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Karma, Rebirth, and Mental Causation [PDF]
, 2007 Attempts to provide a thoroughly naturalized reading of the doctrine of karma have raised important issues regarding its role in the overall economy of the Buddhist soteriological project.
Coseru, Christian
core