Results 101 to 110 of about 92,974 (284)

Promoting and maintaining health of people with sight loss: A scoping study [PDF]

, 2009
This study was undertaken in response to a request by the Thomas Pocklington Trust to identify and explore the following issues: • The needs and concerns regarding immediate risks to health and safety related to sight loss; • Additional risks arising ...
Cattan, M, Hughes, S, Kime, NH, Purcell, M, Woodward, J   +4 more
core  

Using multimedia to enhance the accessibility of the learning environment for disabled students: reflections from the Skills for Access project [PDF]

, 2006
As educators' awareness of their responsibilities towards ensuring the accessibility of the learning environment to disabled students increases, significant debate surrounds the implications of accessibility requirements on educational multimedia.
Gregor, Peter, Sloan, David, Stratford, John   +2 more
core   +2 more sources

Audiological phenotype of siblings with dual sensory impairment caused by SLITRK6 mutation—case report

The Egyptian Journal of Otolaryngology
Background Dual sensory impairment (DSI), defined as concomitant hearing and vision loss, is a rare but clinically significant condition. While genetic factors account for the majority of congenital sensory impairments, dual impairment syndromes are less
Swapna Sebastian, Paul Jasper, Manju Deena Mammen, Ann Mary Augustine   +3 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Event-related brain potential correlates of human auditory sensory memory-trace formation [PDF]

, 2005
The event-related potential (ERP) component mismatch negativity (MMN) is a neural marker of human echoic memory. MMN is elicited by deviant sounds embedded in a stream of frequent standards, reflecting the deviation from an inferred memory trace of the ...
Baldeweg, T, Dwivedi, P, Gruzelier, JH, Haenschel, C, Vernon, DJ   +4 more
core  

Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing-remitting multiple sclerosis [PDF]

, 2015
Background and objective: To define the pathological substrate underlying disability in multiple sclerosis by evaluating the relationship of resting-state functional connectivity with microstructural brain damage, as assessed by diffusion tensor maging ...
Filippini, N, Pantano, Patrizia, Petsas, Nikolaos, Piattella, MARIA CRISTINA, Pozzilli, Carlo, Prosperini, Luca, Sbardella, Emilia, Tona, Francesca, Upadhyay, Neeraj   +8 more
core   +1 more source

A study on the mechanism of how sensory impairment affects depression in the elderly: the mediating roles of daily activity capability and social participation

Frontiers in Psychology
ObjectivesThrough a longitudinal study, we explored the relationship between sensory impairments and depression in the elderly, and examined the mediating roles of daily activity capability and social participation within this relationship.MethodsBased ...
Chunjie Huang, Xiaoqing He, Xin Zhang
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Telephone conversation impairs sustained visual attention via a central bottleneck [PDF]

, 2008
Recent research has shown that holding telephone conversations disrupts one's driving ability. We asked whether this effect could be attributed to a visual attention impairment.
A. Mack, C. D. Wickens, C. D. Wickens, C. D. Wickens, C. M. Herdman, C. Spence, D. A. Allport, D. Fougnie, D. G. Pelli, D. H. Brainard, D. L. Strayer, D. L. Strayer, D. L. Strayer, D. L. Strayer, D. Navon, E. Donchin, E. J. Sirevaag, G. A. Alvarez, G. R. Loftus, H. Pashler, H. Pashler, J. Levy, J. M. Wolfe, J. R. Helleberg, J. S. McCarley, K. M. Arnell, L. H. Shaffer, L. M. Ward, M. Grabowecky, Melina A. Kunar, Michael Cohen, N. A. Macmillan, P. Cavanagh, P. Jolicoeur, R. Allen, R. Dell’Acqua, Randall Carter, T. S. Horowitz, Todd S. Horowitz, V. Briem, Z. W. Pylyshyn   +40 more
core   +2 more sources

The impact of visual and hearing impairments on the risk of arthritis among middle-aged and older Chinese adults (2011–2015): the mediating role of depressive symptoms

BMC Public Health
Background To date, the mechanisms underlying the relationship between sensory impairment and new-onset arthritis remain inadequately understood. This study aims to investigate the mediating role of depressive symptoms in the longitudinal association ...
Chenyang Li, Shuai Ma, Ning Zhang, Jie Yuan, Tengbo Shi, Shanlin Tong, Ying Zhang   +6 more
doaj   +1 more source