Results 101 to 110 of about 1,883,217 (267)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Sensory impairment and risk of incident depression in older adults: a harmonized longitudinal analysis of 72,177 individuals across six international cohorts

Frontiers in Public Health
BackgroundEvidence linking sensory impairment to depression is predominantly Western. We quantified longitudinal associations of single and dual sensory impairment (DSI) with incident depression using harmonized data from six countries.MethodsWe analyzed
Lin Guo, Linlin Zhang, Zengying Zhuang, Yanjie Jiang, Linlin Yue   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The impact of visual and hearing impairments on the risk of arthritis among middle-aged and older Chinese adults (2011–2015): the mediating role of depressive symptoms

BMC Public Health
Background To date, the mechanisms underlying the relationship between sensory impairment and new-onset arthritis remain inadequately understood. This study aims to investigate the mediating role of depressive symptoms in the longitudinal association ...
Chenyang Li, Shuai Ma, Ning Zhang, Jie Yuan, Tengbo Shi, Shanlin Tong, Ying Zhang   +6 more
doaj   +1 more source

A study on the mechanism of how sensory impairment affects depression in the elderly: the mediating roles of daily activity capability and social participation

Frontiers in Psychology
ObjectivesThrough a longitudinal study, we explored the relationship between sensory impairments and depression in the elderly, and examined the mediating roles of daily activity capability and social participation within this relationship.MethodsBased ...
Chunjie Huang, Xiaoqing He, Xin Zhang
doaj   +1 more source

Intervention for mixed receptive-expressive language impairment : a review [PDF]

, 2010
Children with receptive-expressive language impairment (RELI), also referred to as 'receptive language disorder' or 'mixed receptive-expressive disorder',2 form a subset of those with speech, language, and communication needs who commonly have problems ...
O'Hare, Anne E, O'Hare, A., ELSPETH MCCARTNEY, JAMES LAW, McCartney, Elspeth, Boyle, James, JAMES BOYLE, ANNE O’HARE, Law, James   +8 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Other title: Technical Assistance Satisfaction Evaluation Results

, 1997
"November 4, 1997." "TO: Kansas Deaf-Blind Advisory Council Members." "FROM: Joan Houghton, Director, Dual Sensory Impairments Project.
Kansas Dual Sensory Impairments Project.
core   +1 more source

Contribution of social activity participation to the relationship between sensory impairment, physical performance and cognitive decline: a longitudinal study in China

Frontiers in Aging Neuroscience
ObjectivesThis study examined the impact of sensory impairment (hearing and/or vision) combined with poor physical performance on cognitive decline and assessed whether social activity participation mediated this relationship.MethodsMultilevel models ...
Lei Lei, Lei Lei, Yinuo Zhou, Lizhen Ye, Yanfang Yang   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source