Results 81 to 90 of about 92,974 (284)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Visual Acuity does not Moderate Effect Sizes of Higher-Level Cognitive Tasks. [PDF]
, 2016 Background/study contextDeclining visual capacities in older adults have been posited as a driving force behind adult age differences in higher-order cognitive functions (e.g., the "common cause" hypothesis of Lindenberger & Baltes, 1994, Psychology ...
Allen, Philip A +3 more
core +2 more sources
Frontiers in Public HealthBackgroundCross-sectional evidence suggests that persistently short or long sleep duration is associated with sensory impairment. Thus, this study was conducted to investigate the associations between sleep duration and altered sleep duration with ...
Ling Yang +6 more
doaj +1 more source
A case report of Usher's syndrome with psychosis: Challenges in diagnosis and management
Journal of Mental Health and Human Behaviour, 2017 Usher's syndrome is a heterogeneous autosomal recessive disorder characterized by dual sensory impairment in the form of profound congenital hearing loss and progressive visual loss due to retinal degeneration.
Akriti Kamran +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Sensory impairments and caregiver burden: a population-based study of older adults in Thailand
BMC GeriatricsBackground Visual and hearing impairments can increase dependence across the life course; however, their impact may be particularly pronounced in older adults due to age-related functional decline and increased care needs.
Patama Vapattanawong, Ruttana Phetsitong
doaj +1 more source
IMPACT OF DUAL SENSORY IMPAIRMENT ON HEALTH CARE INTERACTION [PDF]
Innov Aging, 2019 Abstract Using data from 46,029,364 Medicare beneficiaries included in the 2015 Current Beneficiary Survey (MCBS), we examined the relationship between dual sensory impairment (DSI) – concurrent vision impairment (VI) and hearing impairment (HI) – and accompaniment to physician visits. Analyses examined reasons for accompaniment and self-
Swenor B +6 more
europepmc +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Cognitive impairment in Parkinson's disease : is it a unified phenomenon? [PDF]
, 2005 Parkinson's disease (PD) has long been associated with dementia. This has been found to correlate with participant age, age at onset of PD and severity of PD.
Brendel, Bettina +2 more
core +1 more source
Sensory Impairment and Health-Related Quality of Life
Iranian Journal of Public Health, 2015 Background: Sensory impairment is a common condition that exerts negative effects on health-related quality of life (HRQoL) in the elderly. This study aimed to determine the relationship between sensory impairment and HRQoL and identify sensory-specific ...
Hye-Jin KWON +4 more
doaj