Results 61 to 70 of about 92,974 (284)

Hearing and vision impairment and social isolation over 8 years in community-dwelling older adults

BMC Public Health
Background Little is known about the long-term impact of hearing and vision impairment on social isolation. This study quantifies the association between hearing, vision, and concurrent hearing and vision impairment (dual sensory impairment) and social ...
Alison R. Huang, Thomas K. M. Cudjoe, George W. Rebok, Bonnielin K. Swenor, Jennifer A. Deal   +4 more
doaj   +1 more source

Impact of single and dual sensory impairments on cognitive function and psychological well-being among older adults in Upper Egypt

Archives of Gerontology and Geriatrics Plus
Background: Dual sensory impairment (DSI), involving both vision and hearing loss, is increasingly recognized as a significant contributor to poor psychological health and cognitive decline in older adults.
Rasha Ahmed Fouad, Esteer Ibrahim Ghayth, Safaa Mostafa Abdeen, Sanaa Mostafa Khalifa   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The effect of a cognitive or motor task on the gait parameters of those with diabetes, with and without neuropathy [PDF]

, 2009
Aims: To compare the gait parameters of older people with diabetes (DM) and people with diabetes and diabetic peripheral neuropathy (DPN) and to investigate the effect of a secondary motor or cognitive task on their gait.
Abboud, Bond, Boulton, Bowen, Cavanagh, Courtemanche, DeMott, Dietz, Duysens, Eils, Faulkner, Folstein, Katoulis, Leinninger, MacKay-Lyons, Maurer, Menz, Mueller, Regnaux, Regnaux, Richardson, Richardson, Tilling, Wollacott, Wong, World Health Organization Study Group   +25 more
core   +1 more source

Severity of dual sensory loss and cognitive impairment in institutionalized older adults: a cross-sectional study in Galicia

BMC Geriatrics
Background Few studies have examined sensory impairment (visual and auditory) as a risk factor for cognitive impairment in older people living in nursing homes. This study analysed the combined effect of visual and auditory impairment (dual sensory loss)
Covadonga Vázquez-Sánchez, Luz María Gigirey Prieto, Carlos Pío del Oro-Sáez   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

THE PSYCHOMOTOR THEORY OF HUMAN MIND [PDF]

, 2007
This study presents a new theory to explain the neural origins of human mind. This is the psychomotor theory. The author briefly analyzed the historical development of the mind-brain theories.
TAN, Prof. Dr. Uner
core   +1 more source

Blast exposure and dual sensory impairment

Journal of Rehabilitation Research and Development, 2012
Combat exposures to blast can result in both peripheral damage to the ears and eyes and central damage to the auditory and visual processing areas in the brain. The functional effects of the latter include visual, auditory, and cognitive processing difficulties that manifest as deficits in attention, memory, and problem solving--symptoms similar to ...
Saunders, Gabrielle H, Echt, Katharina V
openaire   +1 more source

Impact of sight and hearing loss in patients with Norrie disease: advantages of Dual Sensory clinics in patient care

BMJ Paediatrics Open, 2020
Norrie disease (ND) is a rare, X-linked condition of visual and auditory impairment, often presenting with additional neurological features and developmental delays of varying severity.
Jane C Sowden, Corné J Kros, Tony Sirimanna, Waheeda Pagarkar, Ngozi Oluonye, Robert H Henderson   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source