Results 61 to 70 of about 294 (192)

Association of hearing, vision, and dual sensory impairment and risk of Alzheimer’s disease: a nested case-control study

BMC Geriatrics
Background Hearing impairment is a known risk factor for Alzheimer’s disease (AD), although less is known about vision impairment or dual sensory impairment (DSI) as risk factors for AD.
Blair Rajamaki, Kaisa Hokkinen, Aarno Dietz, Kai Kaarniranta, Sirpa Hartikainen, Anna-Maija Tolppanen   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Association of vision and hearing impairment and dietary diversity among the oldest old in China: findings from the Chinese longitudinal healthy longevity survey

BMC Public Health
Background The presence of sensory impairment among older age cohorts exerts a significant impact on both individuals and society generally. Although the impact of dietary patterns on health is vital across all stages of life, there still a paucity of ...
Xinyue Shen, Xuhao Chen, Xiaohong Chen, Zhidong Li, Junxiong Lin, Haishun Huang, Rui Xie, Yiqing Li, Yingting Zhu, Yehong Zhuo   +9 more
doaj   +1 more source

Associations Between Vision and Hearing Impairment and Cardiovascular Diseases: A Longitudinal Cohort of Middle‐Aged and Older Adults in China

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Based on the severity of cardiovascular disease (CVD) and sensory impairment in China and the lack of research on this, the aims of our study were to assess the impact of hearing impairment (HI), visual impairment (VI), and concurrent HI and ...
Jie He, Xiaoyu Tang, Minglan Jiang, Xiaowei Zheng   +3 more
doaj   +1 more source

A case report of Usher's syndrome with psychosis: Challenges in diagnosis and management

Journal of Mental Health and Human Behaviour, 2017
Usher's syndrome is a heterogeneous autosomal recessive disorder characterized by dual sensory impairment in the form of profound congenital hearing loss and progressive visual loss due to retinal degeneration.
Akriti Kamran, Deeksha Elwadhi, Rosali Bhoi, Mahima Malhotra   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A study on cognitive trajectory changes and predictive factors in middle-aged and older adults individuals with dual sensory impairment based on the health social determinants model

Frontiers in Public Health
AimThis study aims to explore the cognitive trajectory changes in middle-aged and older adults individuals with dual sensory impairment (simultaneous visual and hearing impairment) and to identify the predictors of different trajectory changes ...
Li Ma, Jiaxue Pang, Qiankun Liu, Pengyao Li, Juju Huang, Yang Xu, Hui Xie   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Problems of identification of sensory impairments and deafblindness in the nowadays children with congenital disabilities

Современная зарубежная психология
This review provides an overview of the challenges of identifying dual sensory impairment in children with congenital disabilities. The concept of deafblindness and the special needs of the group with hearing and visual impairments are ...
A.Y. Khokhlova, C. Moreau
doaj   +1 more source