Results 41 to 50 of about 294 (192)

Hearing and vision impairment and social isolation over 8 years in community-dwelling older adults

BMC Public Health
Background Little is known about the long-term impact of hearing and vision impairment on social isolation. This study quantifies the association between hearing, vision, and concurrent hearing and vision impairment (dual sensory impairment) and social ...
Alison R. Huang, Thomas K. M. Cudjoe, George W. Rebok, Bonnielin K. Swenor, Jennifer A. Deal   +4 more
doaj   +1 more source

Impact of single and dual sensory impairments on cognitive function and psychological well-being among older adults in Upper Egypt

Archives of Gerontology and Geriatrics Plus
Background: Dual sensory impairment (DSI), involving both vision and hearing loss, is increasingly recognized as a significant contributor to poor psychological health and cognitive decline in older adults.
Rasha Ahmed Fouad, Esteer Ibrahim Ghayth, Safaa Mostafa Abdeen, Sanaa Mostafa Khalifa   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Severity of dual sensory loss and cognitive impairment in institutionalized older adults: a cross-sectional study in Galicia

BMC Geriatrics
Background Few studies have examined sensory impairment (visual and auditory) as a risk factor for cognitive impairment in older people living in nursing homes. This study analysed the combined effect of visual and auditory impairment (dual sensory loss)
Covadonga Vázquez-Sánchez, Luz María Gigirey Prieto, Carlos Pío del Oro-Sáez   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Impact of dual sensory impairment on dementia: A systematic review and meta‐analysis

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Hearing and vision loss are considered independent modifiable risk factors for dementia; however, the impact of their dual impairment is not clear and is crucial for preventive strategies. We performed a systematic review and meta‐analysis until July 23,
Daniele Urso, Stefano Giannoni‐Luza, Ahmed Amine Alaoui, Jeremy Ting, Samir Jabbour, Adrian Fuente, Giancarlo Logroscino   +6 more
doaj   +1 more source

Blast exposure and dual sensory impairment

Journal of Rehabilitation Research and Development, 2012
Combat exposures to blast can result in both peripheral damage to the ears and eyes and central damage to the auditory and visual processing areas in the brain. The functional effects of the latter include visual, auditory, and cognitive processing difficulties that manifest as deficits in attention, memory, and problem solving--symptoms similar to ...
Saunders, Gabrielle H, Echt, Katharina V
openaire   +1 more source

Accessibility of TV media for the dual-sensory impaired in Finland and in the UK

Finnish Journal of eHealth and eWelfare, 2019
One of the most used media is television. Almost all of us have a television set at home. Television is commonly thought also to be accessible, and for most of us, it seems to be so. However, there are people who cannot enjoy televised programmes without special measures.
Stina Ojala, Russ Palmer, Riitta Lahtinen   +2 more
openaire   +5 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source