Results 51 to 60 of about 1,883,217 (267)

Combined Vision and Hearing Difficulties Results in Higher Levels of Depression and Chronic Anxiety: Data From a Large Sample of Spanish Adults

open access: yesFrontiers in Psychology, 2021
ObjectiveIndividually, vision and hearing impairments have been linked to higher levels of anxiety and depression. We investigated the effect of dual sensory impairment (difficulty seeing and hearing) in a large representative sample of Spanish adults ...
Shahina Pardhan   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Longitudinal Associations of Self-Reported Visual, Hearing, and Dual Sensory Difficulties With Symptoms of Depression Among Older Adults in the United States

open access: yesFrontiers in Neuroscience, 2022
Evidence conflicts on the association between sensory difficulty and depression. Few studies have examined this association using longitudinal or population-based data.
Olivia J. Killeen   +14 more
doaj   +1 more source

Reports measuring psychosocial health outcomes for people with dual sensory impairment (DSI).

open access: yes, 2023
Reports measuring psychosocial health outcomes for people with dual sensory impairment (DSI).
Justine H. Zhang (15503104)   +12 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The Effect of Vibrotactile Feedback on Healthy People and People with Vestibular Disorders during Dual-task Conditions [PDF]

open access: yes, 2013
Vibrotactile feedback (VTF) has been shown to improve balance performance in healthy people and people with vestibular disorders in a single-task experimental condition. However, typical balance activities occur in a multi-task environment.
Lin, Chia-Cheng
core  

Characteristics of 183 reports of 153 primary studies reporting dual sensory impairment prevalence or impact.

open access: yes, 2023
Characteristics of 183 reports of 153 primary studies reporting dual sensory impairment prevalence or impact.
Justine H. Zhang (15503104)   +12 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Associations Between Self-Reported Sensory Impairment and Risk of Cognitive Decline and Impairment in the Health and Retirement Study Cohort [PDF]

open access: yes, 2020
Objectives: We aimed to determine whether self-assessed single (hearing or visual) and dual sensory (hearing and visual) impairments are associated with cognitive decline and incident possible cognitive impairment, no dementia (CIND) and probable ...
Meester-Smor, Magda   +20 more
core   +3 more sources

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