Results 131 to 140 of about 150,972 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Prescribing for older people with sensory impairment: a qualitative interview study with independent prescribers in primary care

BMJ Open
Objectives To explore prescribers’ awareness of medicine-related challenges of older people (≥65 years) with sensory impairment (hearing, visual or dual impaired) and identify the influences on prescribing behaviours for these patient populations.Design ...
Margaret C Watson, Brenda Clark Morrison, Marilyn Lennon   +2 more
doaj   +1 more source

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]

, 2014
There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P., Stavenhagen, Jeffrey B., Teeling, Jessica L.   +2 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Associations between sensory impairment and functional limitations among older Chinese adults: mediating roles of social isolation and cognition

BMC Geriatrics
Background The high prevalence of sensory impairment and functional limitations in older adults is a significant concern, yet there is limited understanding of the relationship between these two conditions.
Bo Xin, Yuxin He, Yixin Wu, Di Zhang, Jiaxin Liu, Shan Yang, Panpan Shi, Han Su, Wenhui Jiang   +8 more
doaj   +1 more source

Dual sensory impairment in older adults increases the risk of mortality: a population-based study.

PLoS ONE, 2013
Although concurrent vision and hearing loss are common in older adults, population-based data on their relationship with mortality is limited. This cohort study investigated the association between objectively measured dual sensory impairment (DSI) with ...
Bamini Gopinath, Julie Schneider, Catherine M McMahon, George Burlutsky, Stephen R Leeder, Paul Mitchell   +5 more
doaj   +1 more source

School rules [PDF]

, 2008
Gordon Murray and Alan Dunlop Architects designed an extraordinary, internationally award-winning school that started with a most challenging set of constraints.
Murray, Gordon
core   +1 more source

Telephone conversation impairs sustained visual attention via a central bottleneck [PDF]

, 2008
Recent research has shown that holding telephone conversations disrupts one's driving ability. We asked whether this effect could be attributed to a visual attention impairment.
A. Mack, C. D. Wickens, C. D. Wickens, C. D. Wickens, C. M. Herdman, C. Spence, D. A. Allport, D. Fougnie, D. G. Pelli, D. H. Brainard, D. L. Strayer, D. L. Strayer, D. L. Strayer, D. L. Strayer, D. Navon, E. Donchin, E. J. Sirevaag, G. A. Alvarez, G. R. Loftus, H. Pashler, H. Pashler, J. Levy, J. M. Wolfe, J. R. Helleberg, J. S. McCarley, K. M. Arnell, L. H. Shaffer, L. M. Ward, M. Grabowecky, Melina A. Kunar, Michael Cohen, N. A. Macmillan, P. Cavanagh, P. Jolicoeur, R. Allen, R. Dell’Acqua, Randall Carter, T. S. Horowitz, Todd S. Horowitz, V. Briem, Z. W. Pylyshyn   +40 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Robotic and clinical evaluation of upper limb motor performance in patients with Friedreich's Ataxia: an observational study [PDF]

, 2015
Background: Friedreich’s ataxia (FRDA) is the most common hereditary autosomal recessive form of ataxia. In this disease there is early manifestation of gait ataxia, and dysmetria of the arms and legs which causes impairment in daily activities that ...
Bertini, Enrico, Cappa, Paolo, Carniel, Sacha, Castelli, Enrico, Germanotta, Marco, Petrarca, Maurizio, Rossi, Stefano, Vasco, Gessica   +7 more
core   +2 more sources