Results 71 to 80 of about 7,745,562 (335)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Certain domains of a new matrix constructed by Euler totient and its summation function

AIMS Mathematics
With the aid of the Euler totient function $ \varphi $ and its summation function $ \top $, a new matrix $ \Delta(\varphi, \top) = (\delta(\varphi, \top)_{nk}) $, where \begin{document}$ \delta(\varphi, \top)_{nk} = \left\{ \begin{array} [c]{ccl ...
Merve İlkhan Kara, Dilek Aydın
doaj   +1 more source

A note on the minimum‐norm in dual space approach to some classical linear optimal control problems

The Journal of Engineering, 2023
Some classical optimal control problems of linear systems can be characterized as finding minimum‐norm vectors from within linear varieties in appropriate dual spaces.
Yue Zhou, Pushkin Kachroo, Kaan Ozbay
doaj   +1 more source

Some topological invariants and biorthogonal systems in Banach spaces [PDF]

, 2011
We consider topological invariants on compact spaces related to the sizes of discrete subspaces (spread), densities of subspaces, Lindelof degree of subspaces, irredundant families of clopen sets and others and look at the following associations between ...
Koszmider, Piotr
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Slant helices, Darboux helices and similar curves in dual space D3 [PDF]

Mathematica Moravica, 2016
In this paper, we give definitions and characterizations of slant helices, normalized Darboux helices and similar curves in dual space D3. First, we define dual slant helices and dual normalized Darboux helices and show that dual slant helices are also ...
Sahiner Burak, Önder Mehmet
doaj  

The celestial chiral algebra of self-dual gravity on Eguchi-Hanson space

Journal of High Energy Physics, 2023
We consider the twistor description of classical self-dual Einstein gravity in the presence of a defect operator wrapping a certain ℂℙ1. The backreaction of this defect deforms the flat twistor space to that of Eguchi-Hanson space.
Roland Bittleston, Simon Heuveline, David Skinner   +2 more
doaj   +1 more source

Shear-induced rigidity of frictional particles: Analysis of emergent order in stress space

, 2016
Solids are distinguished from fluids by their ability to resist shear. In traditional solids, the resistance to shear is associated with the emergence of broken translational symmetry as exhibited by a non-uniform density pattern, which results from ...
Behringer, R. P., Bi, Dapeng, Chakraborty, Bulbul, Ren, Jie, Sarkar, Sumantra, Zhang, Jie   +5 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Strictly convex norms and topology

, 2010
We introduce a new topological property called (*) and the corresponding class of topological spaces, which includes spaces with $G_\delta$-diagonals and Gruenhage spaces.
Orihuela, José, Smith, Richard J., Troyanski, Stanimir   +2 more
core   +1 more source