Results 91 to 100 of about 3,009,034 (256)

Dual-task interference: Attentional and neurophysiological influences

open access: yes, 2009
Performing two tasks simultaneously often degrades performance of one or both tasks. While this dual-task interference is classically interpreted in terms of shared attentional resources, where two motor tasks are performed simultaneously interactions ...
Jeffery Summers (14750413)   +3 more
core  

Differences in dual-task performance and prefrontal cortex activation between younger and older adults

open access: yesBMC Neuroscience, 2013
Background The purpose of this study was to examine task-related changes in prefrontal cortex (PFC) activity during a dual-task in both healthy young and older adults and compare patterns of activation between the age groups.
Ohsugi Hironori   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Illinois Terrorism Task Force- 2004 Annual Report [PDF]

open access: yes, 2005
This report documents the activities and accomplishments of the Illinois Terrorism Task Force during the year 2004.Submitted by Adam Groves (agroves@fsi.uiuc.edu) on 2006-09-22T16:01:23Z No.
Illinois Terrorism Task Force
core  

Walking in school-aged children in a dual-task paradigm is related to age but not to cognition, motor behavior, injuries, or psychosocial functioning

open access: yesFrontiers in Psychology, 2016
Age-dependent gait characteristics and associations with cognition, motor behavior, injuries, and psychosocial functioning were investigated in 138 typically developing children aged 6.7 to 13.2 years (M =10.0 years).
Priska eHagmann-von Arx   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Illinois Terrorism Task Force- 2007 Annual Report [PDF]

open access: yes, 2008
This report documents the activities and accomplishments of the Illinois Terrorism Task Force during the year 2007.not peer reviewedSubmitted by Adam Groves (agroves@fsi.uiuc.edu) on 2008-07-03T15:32:48Z No. of bitstreams: 1 Illinois Terrorism Task Force-
Illinois Terrorism Task Force
core  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Effects of single-task and dual-task demands on force control during bimanual coordination in healthy young adults

open access: yes
Burciu, RoxanaBackground: People often use both hands simultaneously to accomplish everyday tasks, and occasionally they do so while also attending to a cognitive task.
Crisomia, Sophia
core   +1 more source

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