Results 51 to 60 of about 3,009,034 (256)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2012 We investigated the effect of increases in task complexity on the dual-task draw-and-pass performance of professional rugby league players. Moreover, we determined the relationship between dual-task draw-and-pass proficiency measured in isolation and ...
Gabbett, Tim J., Abernethy, Bruce
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Application and Research of Dual-Task Paradigms in Central Nervous System Diseases
康复学报, 2022 The ability to perform two or more tasks simultaneously in activities of daily living is essential. The cognitive-motor dual-task paradigm refers to the simultaneous performance of a cognitive task and a motor task, where the cognitive task can be ...
LI Qinyi +9 more
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Testing-the-limits of optimizing dual-task performance in younger and older adults
Frontiers in Human Neuroscience, 2012 Impaired dual-task performance in younger and older adults can be improved with practice. Optimal conditions even allow for a (near) elimination of this impairment in younger adults.
Tilo eStrobach +4 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Effects of Gait and Cognitive Task Difficulty on Cognitive-Motor Interference in Aging
Journal of Aging Research, 2012 Although gait-related dual-task interference in aging is well established, the effect of gait and cognitive task difficulty on dual-task interference is poorly understood.
Prudence Plummer-D'Amato +5 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Dual-task costs while turning.
, 2020 Dual-task costs (DTC) of HD participants during turns; Results of a two-tailed independent sample t-test indicating significant cognitive interference observed for turn duration (p = 0.013) (A) and number of steps to turn (p = 0.029) (B) in HD compared ...
Joan A. O’Keefe (8259825) +5 more
core +1 more source