Results 191 to 200 of about 533,374 (260)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Different modulation patterns of theta and gamma dual-site HD-tACS on cognitive impairment. [PDF]

open access: yesiScience
Hao W   +8 more
europepmc   +1 more source

HPV genotype-specific p16/Ki67 expression with machine learning-assisted assessment in cervical neoplasia. [PDF]

open access: yesFront Oncol
Kececi Oguzhanoglu M   +5 more
europepmc   +1 more source

New gait performance indices and cognitive functions: a longitudinal pre-post follow-up after rehabilitation in people with Parkinson's disease. [PDF]

open access: yesFront Hum Neurosci
Cocco ES   +12 more
europepmc   +1 more source

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