Results 41 to 50 of about 14,224,950 (283)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

No U(1) ‘electric-magnetic’ duality in Einstein gravity

Journal of High Energy Physics
We revisit the question of whether classical general relativity obeys, beyond the linearised order, an analogue of the global U(1) electric-magnetic duality of Maxwell theory, with the Riemann tensor playing the role analogous to the field strength ...
Ricardo Monteiro
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A non-relativistic limit of M-theory and 11-dimensional membrane Newton-Cartan geometry

Journal of High Energy Physics, 2021
We consider a non-relativistic limit of the bosonic sector of eleven-dimensional supergravity, leading to a theory based on a covariant ‘membrane Newton-Cartan’ (MNC) geometry.
Chris D. A. Blair, Domingo Gallegos, Natale Zinnato   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Higher-derivative corrections via the double copy procedure

Journal of High Energy Physics
Recent advances in the off-shell formulation of the Double Copy (DC) procedure have revealed a profound connection between gauge theories and T-duality invariant frameworks.
Eric Lescano, Jesus A. Rodriguez
doaj   +1 more source

The Effect of the Board Characteristics and Management Entrenchment on Firm Diversification Strategy [PDF]

راهبرد مدیریت مالی, 2017
The purpose of this paper is to examine the effect of the board characteristics and the management entrenchment on the diversification strategy at firms listed in Tehran Stock Exchange. In this regard, 110 companies were selected for the period 2008-2014.
Vahid Taghizadeh Khanqah, Mehdi Zeinali
doaj   +1 more source

D-branes, RR-fields and duality on noncommutative manifolds

, 2008
We develop some of the ingredients needed for string theory on noncommutative spacetimes, proposing an axiomatic formulation of T-duality as well as establishing a very general formula for D-brane charges.
Szabo, Richard J.; id_orcid, Jonathan Rosenberg, Rosenberg, J., Varghese Mathai, Richard J. Szabo, Varghese, M., Jacek Brodzki, Brodzki, Jacek, Rosenberg, Jonathan, Szabo, R., J. Szabo, Szabo, Richard J., Richard, Brodzki, J., Mathai, Varghese   +14 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source