Results 61 to 70 of about 12,152 (266)
Dualities in supersymmetric field theories [PDF]
Nuclear Physics B - Proceedings Supplements, 1998 9 pages, latex with espcrc2 ...
openaire +3 more sources
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
The holography of non-invertible self-duality symmetries
Journal of High Energy PhysicsWe study how non-invertible self-duality defects arise in theories with a holographic dual. We focus on the paradigmatic example of su N $$ \mathfrak{su}(N) $$ N $$ \mathcal{N} $$ = 4 SYM.
Andrea Antinucci +4 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Non-invertible symmetries along 4d RG flows
Journal of High Energy PhysicsWe explore novel examples of RG flows preserving a non-invertible self-duality symmetry. Our main focus is on N $$ \mathcal{N} $$ = 1 quadratic superpotential deformations of 4d N $$ \mathcal{N} $$ = 4 super-Yang-Mills theory with gauge algebra su N ...
Jeremias Aguilera Damia +5 more
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
When are duality defects group-theoretical?
Journal of High Energy PhysicsA quantum field theory with a finite abelian symmetry G may be equipped with a non-invertible duality defect associated with gauging G. For certain G, duality defects admit an alternative construction where one starts with invertible symmetries with ...
Zhengdi Sun, Yunqin Zheng
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source