Results 51 to 60 of about 12,152 (266)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Nonrelativistic string theory and T-duality
Journal of High Energy Physics, 2018 Nonrelativistic string theory in flat spacetime is described by a two-dimensional quantum field theory with a nonrelativistic global symmetry acting on the worldsheet fields. Nonrelativistic string theory is unitary, ultraviolet complete and has a string
Eric Bergshoeff, Jaume Gomis, Ziqi Yan
doaj +1 more source
Group dualities, T‐dualities, and twisted K‐theory
Journal of the London Mathematical Society, 2017 29 pages, mild ...
Varghese Mathai, Jonathan Rosenberg
openaire +4 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Graded Clifford Theory and Duality
Journal of Algebra, 1993 The main goal of this paper is to compare, using duality methods, the left graded Clifford theory defined by \(S\), a graded-simple left module, with the right graded Clifford theory defined by a graded-simple module which can be associated to \(S\), when the countermodule of \(S\) is finitely generated.
Pardo, J.L.G., Nastasescu, C.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Duality in the optimal control of hyperbolic equations with positive controls
International Journal of Mathematics and Mathematical Sciences, 2000 We study the duality theory for hyperbolic equations. Also, we consider distributed control systems with positive control and convex cost functionals.
Jong Yeoul Park, Mi Jin Lee
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Duality theorems in deformation theory [PDF]
Transactions of the American Mathematical Society, 1985 We give a unified treatment of the construction of the Calabi sequence, which is a resolution of the sheaf of Killing vector fields on a Riemannian manifold of constant curvature, and of the resolution of the sheaf of conformal Killing vector fields on a conformally flat Riemannian manifold of dimension
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source