Results 51 to 60 of about 2,097 (305)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Aleksandras Čyras and optimization in structural mechanics
Journal of Civil Engineering and Management, 2002 The study describes how in Lithuania (mostly in Vilnius) during some past decades a new trend of investigations in structural mechanics thanks to Aleksandras Čyras' (1927–2001) research and organisational activities has been developed.
Juozas Atkočiūnas, Algirdas Čižas
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Inverse kinematics for the variable geometry truss manipulator via a Lagrangian dual method
International Journal of Advanced Robotic Systems, 2016 This article studies the inverse kinematics problem of the variable geometry truss manipulator. The problem is cast as an optimization process which can be divided into two steps.
Yanchun Zhao +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
Multi-Energy Microgrid Low-Carbon Optimization Scheduling and Robust Solution Method with Low Conservatism Based on Collaborative Comprehensive Demand Side Response [PDF]
Dianli jianshe[Objective] To address the negative impacts of renewable energy and load uncertainty on the economic performance and low-carbon optimization operation of multi-energy microgrids，this paper explores the potential of comprehensive demand response and ...
YANG Chen, WANG Long, WANG Zongyi, JIN Xin, PAN Tingzhe
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart +14 more
wiley +1 more source
A Stochastic Nash Equilibrium Problem for Crisis Rescue
AxiomsThis paper proposes a two-stage stochastic non-cooperative game model to solve relief supplies procurement and distribution optimization of multiple rescue organizations in crisis rescue.
Cunlin Li, Yiyan Li
doaj +1 more source
Topology optimization of a load-bearing structure via the method of convex linearization
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2018 A method of topology optimization based on the convex linearization approach is proposed. The problem formulation implies minimization of the strain energy of a structure subject to volume constraint.
E. A. Kishov, V. A. Komarov
doaj +1 more source
Arthritis Care &Research, Accepted Article.Objective Knee osteoarthritis (OA) commonly affects individuals with Type 2 diabetes (T2DM) and is associated with increased risk of diabetes‐related complications. To better understand potential mechanisms, we examined the association between symptomatic knee OA and glycemic control in individuals with T2DM.
Lauren K. King +10 more
wiley +1 more source